Health problems running in family may be due to poor vitamin D (hypertension, VDR in this case)

Created September 2022

Evidence of a causal relationship between vitamin D deficiency and hypertension: a family-based study

Hypertens Res . 2022 Sep 5. doi: 10.1038/s41440-022-01004-0   PDF is behind a $32 paywall

Lanxin Bai 1 , Chenling Qu 2 , Yinhua Feng 1 , Gangqiong Liu 3 , Xing Li 1 , Wenjie Li 1 , Songcheng Yu 4 5

An association between vitamin D deficiency and hypertension has been observed in numerous studies. However, blood pressure improvements resulting from supplementation with vitamin D have been inconsistent. The causal relationship between vitamin D deficiency and hypertension is still unclear and was investigated in this family-based study. A total of 1370 individuals from both vitamin D deficiency and hypertension families were included. First, the heritability of vitamin D deficiency was estimated by the Falconer method. Second, SNPs (single nucleotide polymorphisms) of vitamin D metabolic and functional pathway genes associated with vitamin D deficiency were screened by a family-based association test, and the findings were further verified in nuclear families with vitamin D deficiency. Finally, a family-based association test was applied to investigate the association between selected SNPs associated with vitamin D deficiency and hypertension. The heritability of vitamin D deficiency was 50.4% in this family-based study. Allele C of rs3847987 was a risk factor for vitamin D deficiency (OR: 1.639, 95% CI: 1.170-2.297, P = 0.004). Furthermore, a family-based association of rs3847987 with hypertension was found in both additive and recessive models (P < 0.05). In addition, vitamin D deficiency was associated with hypertension ( OR: 1.317 , 95% CI: 1.022-1.698, P = 0.033).

In conclusion, rs3847987 in the VDR gene was associated with both vitamin D deficiency and hypertension. Therefore, vitamin D deficiency may be a causal factor for hypertension.

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VitaminDWiki - The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019__

VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

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Diseases associated with a poor Vitamin D Receptor

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VitaminDWiki - studies in both categories Hypertension and Vitamin D Receptor

This list is automatically updated

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A few other family associations in VitaminDWiki

Tags: Hypertension Vit D Receptor