Familial Mediterranean Fever is associated with poor genes (and a poor vitamin D receptor)
Serum Vitamin D Levels In Pediatric Patients With Familial Mediterranean Fever
Journal of Clinical Pediatrics and Care. 3(1); DOI: 10.58489/2836-8630/011
Ahmet Ibrahim KURTOGLU MD, Phd1*, Bayram Ali DORUM MD, Associate Professor2, Vefik ARICA MD Professor3,
Utku OZER MD4, Murat TUTANC Professor 5
1 Adana City Hospital Neonatology Department ADANA/TURKEY.
2 Bursa City Hospital Neonatal Department BURSA/TURKEY.
3 University of Yalova Pediatrics Department YALOVA/TURKEY.
4 Adana City Hospital Pediatrics Emergency Department ADANA/TURKEY.
5 Bursa City Hospital Pediatrics Department BURSA/TURKEY.
Corresponding Author: Ahmet Ibrahim KURTOGLU, Adana City Hospital Neonatalogy Department ADANA/TURKEY.
Introduction: Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disorder. Vitamin D deficiency is a common finding in patients with various chronic inflammatory diseases. Several studies have elucidated the correlation between serum vitamin D levels and disease activity in pediatric Familial Mediterranean Fever patients. In this study, we aimed to investigate the role of vitamin D in the development of Familial Mediterranean.
Method: This study includes 95 pediatric patients diagnosed with Familial Mediterranean Fever who were followed by the Department of Pediatrics at an Application and Research Hospital in Turkey and agreed to participate in the study. Additionally, 34 healthy children who consented to participate constituted the control group. The diagnosis of patients with FMF utilized the Tel-Hashomer criteria
Results: The hormone levels of FMF and control groups were compared. Vitamin D levels, calcium, phosphorus, Parathyroid Hormone and Alkaline Phosphatase levels were analyzed. In the FMF group, the Vitamin D level was found to be significantly lower, while the Ca and phosphorus levels were significantly higher compared to the control group (both with p<0.01). Although the difference in Ca levels between the two groups was statistically significant, the mean Ca levels of both groups remained within the normal range.
Conclusion: In conclusion, the significant deficiency of serum vitamin D levels in pediatric FMF patients and its association with disease severity underscores the importance of regular monitoring and potential therapeutic intervention.
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What was found by asking Perplexity a few questions
- FMF is caused by mutations in the MEFV gene, inherited in an autosomal recessive pattern.
$Periods between FMF attacks are symptom-free, ranging from days to years.
Colchicine is the primary treatment for FMF
FMF incidence in Turkey is between 1 in 400 and 1 in 1,000 people * 1. People with FMF who are resistant to Colchicine have low vitamin D levels
the AA genotype of the BsmI VDR polymorphism = 2.62-fold higher risk of FMF in males
Curcumin helps treat FMF
- but, we also know that Curcumin activates the Vitamin D receptor
- So, for 2 reasons we suspect the FMF is related to the vitamin D receptor
5+ VitaminDWiki pages have FMF etc. in the title
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VitaminDWiki - Vitamin D Receptor can be activated by Curcumin, etc
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