Every Parkinson’s brain had a gene modification that limited how much vitamin D was available (CYP27B1)

Astrocytes expressing Vitamin D-activating enzyme identify Parkinson's disease - Feb 2022

CNS Neurosci Ther. 2022 Feb 15. doi: 10.1111/cns.13801

Samanta Mazzetti 1 2, Michela Barichella 2 3, Federica Giampietro 1, Angelica Giana 1 3, Alessandra M Calogero 1, Alida Amadeo 1 4, Nicola Palazzi 1, Alessandro Comincini 1, Giorgio Giaccone 5, Manuela Bramerio 6, Serena Caronni 2 3, Viviana Cereda 2 3, Emanuele Cereda 7, Graziella Cappelletti 1 4, Chiara Rolando 1, Gianni Pezzoli 2 3

Introduction: Astrocytes are involved in Parkinson's disease (PD) where they could contribute to α-Synuclein pathology but also to neuroprotection via α-Synuclein clearance. The molecular signature underlying their dual role is still elusive. Given that vitamin D has been recently suggested to be protective in neurodegeneration, the aim of our study was to investigate astrocyte and neuron vitamin D pathway alterations and their correlation with α-Synuclein aggregates (ie, oligomers and fibrils) in human brain obtained from PD patients.

Methods: The expression of vitamin D pathway components CYP27B1, CYP24A1, and VDR was examined in brains obtained from PD patients (Braak stage 6; n = 9) and control subjects (n = 4). We also exploited proximity ligation assay to identified toxic α-Synuclein oligomers in human astrocytes.

Results: We found that vitamin D-activating enzyme CYP27B1 identified a subpopulation of astrocytes exclusively in PD patients. CYP27B1 positive astrocytes could display neuroprotective features as they sequester α-Synuclein oligomers and are associated with Lewy body negative neurons.

Conclusion: The presence of astrocytes distinguishes PD patients and suggests their contribution to protect neurons and to ameliorate neuropathological traits.

VitaminDWiki - CYP27B1 category listing contains:

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VitaminDWiki - Other

• Gene mutations which restrict Vitamin D activation (CYP27B1) results in many health problems – March 2020

• Genes which regulate active vitamin D worsen with age – Oct 2016 -Including CYP27B1

• Does survival of the less fit mean less health (poor genes may be inherited)

VitaminDWiki - Vitamin D Receptor Gene probably more important

VitaminDWiki - Vitamin D Receptor category has

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VitaminDWiki - The Vitamin D Receptor is associated with many health problems

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• ((Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016)