Enlarged Prostate (BPH) and Vitamin D - several studies

Created March 2024

4+ VitaminDWiki pages have BPH in the title

This list is automatically updated

{LIST()}

BPH about 50% more likely if poor VDR – meta-analysis March 2024

Association between vitamin D receptor gene polymorphisms and genetic susceptibility to benign prostatic hyperplasia: A systematic review and meta-analysis

Medicine (Baltimore) 2024 Mar 1;103(9):e37361. doi: 10.1097/MD.0000000000037361.

Li Ruan 1

Background: Benign prostatic hyperplasia (BPH) is one of the global public health challenges due to the complexity of its mechanisms of occurrence. Many studies have suggested that vitamin D receptor gene polymorphisms are associated with BPH susceptibility. Still, their conflicting findings need to be analyzed in aggregate to gain a better understanding.

Methods: We identified 10 trials involving 1539 BPH cases and 1915 controls through a systematic search of Embase using, data obtained from the Web of Science, PubMed, and China Knowledge Network databases as of December 31, 2021. A meta-analysis was performed to investigate the association between 4 constant polymorphisms of this associated vitamin D receptor gene (Fok-1, Bsm-1, Taq-1, and Apa-1) and BPH risk.

Results: In the overall population analysis, a significant positive association with BPH risk was found only in the Taq-1 variant (P < .001). Of these, the pure-hybrid model (95% confidence interval [CI] = 1.384-3.196), the heterozygous model (95% CI = 1.207-2.021), the dominant model (95% CI = 1.312-2.133) and the allelic inheritance model (95% CI = 1.205-1.730) showed low heterogeneity. In subtype analyses, Bsm-1 variants showed a significant association with BPH risk for both the recessive (95% CI = 0.100-0.943, P = .039) and over-dominant (95% CI = 1.553-3.100, P = 0) models in the Caucasian population, and for the recessive (95% CI = 1.242-3.283, P = .039) and over-dominant (95% CI = 0.281-0.680, P = 0) models in the Asian population. In addition, a high degree of heterogeneity was found in the subgroup analysis of the association between Fok-1 variants and BPH risk.

Conclusion: Overall, there is an association between vitamin D receptor polymorphisms and BPH risk. Identification of BPH susceptibility by vitamin D receptor gene polymorphisms has potential.

31 References

  • Lerner LB, McVary KT, Barry MJ, et al. Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA GUIDELINE PART I—initial work-up and medical management. J Urol. 2021;206:806–17.

  • Devlin CM, Simms MS, Maitland NJ. Benign prostatic hyperplasia—what do we know? BJU Int. 2021;127:389–99.

  • Qian XQ, Xu D, Liu HL, et al. Genetic variants in 5p13.2 and 7q21.1 are associated with treatment for benign prostatic hyperplasia with the alpha-adrenergic receptor antagonist. Aging Male. 2017;20:250–6.

  • Na R, Helfand BT, Chen HT, et al. A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). prostate . 2017;77:1213–20.

  • AlChalabi R, Wali MH, Al-Ugaili DN, et al. Association between single nucleotide polymorphisms of vitamin D receptor gene and diabetes with progression of benign prostatic hyperplasia. Ann Trop Med Public Health. 2020;23:444–54.

  • Kayode OT, Owolabi AV, Kayode AAA. Biochemical and histomorphological changes in testosterone propionate-induced benign prostatic hyperplasia in male Wistar rats treated with ketogenic diet. Biomed Pharmacother. 2020;132:110863.

  • Chaimuangraj S, Thammachoti R, Ongphiphadhanakul B, et al. Lack of association of VDR polymorphisms with Thai prostate cancer as compared with benign prostate hyperplasia and controls. Asian Pac J Cancer Prev. 2006;7:136–9.

  • Manchanda PK, Konwar R, Nayak VL, et al. Association of genetic variants of the vitamin D receptor (VDR) gene (Fok-1, Taq-1 & Bsm-1) with susceptibility of benign prostatic hyperplasia in a North Indian population. Asian Pac J Cancer Prev. 2010;11:1005–8.

  • Zeng XT, Yao QS, Weng H, et al. Meta-analysis of vitamin D receptor gene polymorphisms and benign prostatic hyperplasia risk. Mol Biol Rep. 2014;41:6713–7.

  • Lu C, Zhou W, He X, et al. Vitamin D status and vitamin D receptor genotypes in celiac disease: a meta-analysis. Crit Rev Food Sci Nutr. 2021;61:2098–106.

  • Barry EL, Peacock JL, Rees JR, et al. vitamin D receptor genotype, vitamin D3 supplementation, and risk of colorectal adenomas: a randomized clinical trial. JAMA Oncol. 2017;3:628–35.

  • Latacz M, Rozmus D, Fiedorowicz E, et al. vitamin D receptor (VDR) gene polymorphism in patients diagnosed with colorectal cancer. Nutrients. 2021;13:200.

  • Huang SP, Huang CY, Wu WJ, et al. Association of vitamin D receptor Fok-1 polymorphism with prostate cancer risk, clinicopathological features and recurrence of prostate specific antigen after radical prostate ctomy. Int J Cancer. 2006;119:1902–7.

  • Zhou Q, Wen S, Liu M, et al. Association between gene polymorphisms of vitamin D receptor and gestational diabetes mellitus: a systematic review and meta-analysis. Int J Environ Res Public Health. 2020;18:205.

  • Bousemaa JT, Bussemakers MJG, Houwelingen KP, et al. Polymorphisms in the vitamin D receptor gene and the androgen receptor gene and the risk of benign prostatic hyperplasia. Eur Urol. 2000;37:234–8.

  • El-Ezzi AA, Zaidan WR, El-Saidi MA, et al. Association of benign prostate hyperplasia with polymorphisms in VDR, CYP17, and SRD5A2 genes among Lebanese men. Asian Pac J Cancer Prev. 2014;15:1255–62.

  • Zhang LL, Song Y, He LL, et al. Associations of SRD5A2/CYP17/CYP19/VDR gene polymorphisms with the development and clinical progression of benign prostatic hyperplasia: a case-control study in northern Chinese population. Int J Clin Exp Pathol. 2017;10:8660–76.

  • Ruan L, Zhu JG, Pan C, et al. Association between single nucleotide polymorphism of vitamin D receptor gene Fok-1 polymorphism and clinical progress of benign prostatic hyperplasia. ScientificWorldJournal. 2015;2015:235895.

  • Schatzl G, Gsur A, Bernhofer G, et al. Association of vitamin D receptor and 17 Hydroxylase Gene polymorphisms with benign prostatic hyperplasia and Benign prostatic enlargement. Urology. 2000;57:567–72.

  • Habuchi T, Suzuki T, Sasaki R, et al. Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population. Cancer Res. 2000;60:305–8.

  • Nunes SBR, Oliveira FM, Neves AF, et al. Association of vitamin D receptor variants with clinical parameters in prostate cancer. Springerplus. 2016;5:364.

  • Hamasaki T, Inatomi H, Katoh T, et al. Significance of vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese. Urol Int. 2002;68:226–31.

  • Lee Ch L, Lee J, Na YJ, et al. Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea. J Exerc Rehabil. 2016;12:504–8.

  • Taheri M, Pouresmaeili F, Omrani MD, et al. Association of ANRIL gene polymorphisms with prostate cancer and benign prostatic hyperplasia in an Iranian population. Biomark Med. 2017;11:413–22.

  • Manchanda PK, Kibler AJ, Zhang M, et al. vitamin D receptor as a therapeutic target for benign prostatic hyperplasia. Indian J Urol. 2012;28:377–81.

  • Lin L, Li P, Liu X, et al. Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia. Syst Rev. 2022;11:60.

  • Mullan RJ, Bergstralh EJ, Farmer SA, et al. Growth factor, cytokine, and vitamin D receptor polymorphisms and risk of benign prostatic hyperplasia in a community-based cohort of men. Urology. 2006;67:300–5.

  • Kim SK, Chung JH, Park HC, et al. Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia. Exp Ther Med. 2015;10:1990–4.

  • Swami S, Krishnan AV, Feldman D. Vitamin D metabolism and action in the prostate : implications for health and disease. Mol Cell Endocrinol. 2011;347:61–9.

  • Ruiz-Ballesteros AI, Meza-Meza MR, Vizmanos-Lamotte B, et al. Association of vitamin D metabolism gene polymorphisms with autoimmunity: evidence in population genetic studies. Int J Mol Sci. 2020;21:9626.

  • Brustad N, Greve JH, Mirzakhani H, et al. High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze. Pediatr Allergy Immunol. 2021;32:679–89.

VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

{include}

VitaminDWiki – Vitamin D Receptor category contains

{include}