Early-Onset Dementia 1.6X more likely if low Vitamin D

Created January 2024

"The study included 356,052 participants younger than 65 years (mean baseline age, 54.6 years) without dementia from the UK Biobank, an ongoing prospective cohort study."
"During a mean follow-up of 8.12 years, there were 485 incident YOD cases (incidence rate of 16.8 per 100,000 person-years; 95% CI 15.4-18.3)."
"The final analysis identified 15 risk factors associated with significantly higher incidence of YOD, including traditional factors like
stroke (hazard ratio [HR], 2.07),
heart disease (HR, 1.61),
diabetes (HR, 1.65), and
depression (HR, 3.25) but also less-recognized risk factors like
vitamin D deficiency (< 10 ng/mL; HR, 1.59) ,
high CRP levels (> 1 mg/dL; HR, 1.54),
and social isolation (infrequent visits to friends or family; HR, 1.53),
with lower socioeconomic status (HR, 1.82),
having two apolipoprotein E epsilon-4 alleles (HR, 1.87),
orthostatic hypotension, which the authors said may be an early sign of Parkinson's dementia or Lewy body dementia (HR, 4.20), and
hearing impairment (HR, 1.56) also increases risk."

Suspect "unadjusted" Vitamin D is > 3X

Reporting on: Risk Factors for Young-Onset Dementia in the UK Biobank

Stevie Hendriks, PhD1; Janice M. Ranson, PhD2; Kirsten Peetoom, PhD1

The abstract is data-free. The PDF is not free: it costs $40 doi:10.1001/jamaneurol.2023.4929

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