Diabetes, immune system and Vitamin D – book chapter – 2019

Created December 2019

Vitamin D in immune regulation

and diabetes mellitus – Chapter 22

Ihor Shymanskyi, Olha Lisakovska, Dmytro Labudzinskyi, Anna Mazanova and Mykola Veliky

Department of Biochemistry of Vitamins and Coenzymes, Palladin Institute of Biochemistry of National

Academy of Sciences of Ukraine, Kyiv, Ukraine
22.1 Introduction 428
22.2 Vitamin D synthesis and activation 428
22.3 Role of vitamin D in immune regulation and inflammatory responses 432
22.3.1 Vitamin D and innate immunity 432
22.3.2 Vitamin D and adaptive immunity 433
22.3.3 Cytokines in regulation of vitamin D-metabolizing enzymes 434
22.4 Vitamin D and diabetes mellitus 435
22.4.1 Vitamin D modulates β-cell function 435
22.4.2 Vitamin Dauto/paracrine system in diabetes mellitus 437
22.4.3 Antiinflammatory effect of vitamin D in diabetes mellitus 438
22.5 Conclusions 442
References (at bottom of VitaminDWiki page) 443
* Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018 * Diabetic inflammation reduced by Vitamin D – meta-analysis Feb 2018 1. Overview Diabetes and vitamin D contains the following {include} Diabetic Epidemic {include} --- 1. Immunity category starts with {include}

📄 Download the PDF from Sci-Hub via VitaminDWiki

Diabetes increases the expression (2) of CPY24A1
which destroys Vitamin D after it is seen by Vit D blood test
Thus preventing Vitamin D from benefiting tissues
(3) Addition of Vitamin D decreases the CYP24A1 expression

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Tags: Diabetes Immunity