Depression more likely if low vitamin D (3.5 X prediabetic women in this case)

Created October 2022

Association between serum 25 (OH) D levels and depression symptoms in adults with prediabetes

Diabetes Metab Syndr. 2022 Oct 13;16(11):102642. doi: 10.1016/j.dsx.2022.102642 pdf behind a paywell

Thi Quynh Chi Vu 1 , Quoc Kham Tran 2 , Kaijun Niu 3

Background and aim: Depression symptoms are a significant risk factor for prediabetes-related diabetes, and low vitamin D levels are connected with depression symptoms. The goal of this study is to examine the association between vitamin D and depression symptoms in prediabetic persons.

Methods: This cross-sectional survey was conducted in Tianjin, China, among 4051 individuals. Symptoms of depression were assessed using the Self-Rating Depression Scale (SDS) (cut-off point SDS ≥45). Serum 25 (OH) D concentrations were determined using an enzyme immunoassay (OCTEIA 25-hydroxy Vitamin D, IDS Ltd, UK) and classified into three levels: 50 nmol/L, 50-75 nmol/L, and >75 nmol/L. The link between serum 25 (OH) D concentrations and depression symptoms in prediabetes was investigated using multiple logistic regression analysis. The models were adjusted for a variety of potential confounders.

Results: The prevalence of symptoms of depression in prediabetic adults was 14.2% (12.5% males and 16.4% females). After adjusting for potentially confounding variables, the odds ratios - ORs for symptoms of depression in women across serum 25 (OH) D levels were 1.00 (reference), 1.03 (0.57, 1.39), and 0.28 (0.12, 0.57), respectively (p = 0.0015). However, no statistically significant connection was discovered in males.

Conclusion: In women with prediabetes, we showed a substantial negative connection between serum 25 (OH) D levels and depressed symptoms. Vitamin D supplementation may be an effective way to decrease the risk of depression symptoms in women with prediabetes.

Note: Diabetes lowers vitamin D; Depression is associated with low vitamin D

Intervention of Vitamin D for Depression

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Meta-analyses of Vitamin D and Depression

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3 related studies on the web

  • Omega-3 supplementation and diabetes: A systematic review and meta-analysis - Jan 2021 https://doi.org/10.1080/10408398.2021.1875977 - $55 PDF

  • Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial - Sept 2021 https://doi.org/10.1002/brb3.2342 FREE PDF

  • The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus: A narrative review Dec 2018 https://doi.org/10.1016/j.jnim.2018.02.002 FREE PDF

Tags: Depression Diabetes