Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023

Created November 2022

Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis - Oct 2022

Heliyon . 2022 Oct 28;8(11):e11290. doi: 10.1016/j.heliyon.2022.e11290

Huzaifa Ahmad Cheema 1 2 , Maurish Fatima 2 , Abia Shahid 1 2 , Oumnia Bouaddi 3 , Anas Elgenidy 4 , Aqeeb Ur Rehman 2 , Salah Eddine Oussama Kacimi 5 , Mohammad Mehedi Hasan 6 , Ka Yiu Lee 7

Introduction: Previous randomized controlled trials (RCTs) and meta-analyses of RCTs evaluating vitamin D supplementation for the prevention of cancer incidence and mortality have found inconsistent results and no meta-analysis has assessed the quality of the evidence available. We, therefore, aimed to perform an updated meta-analysis by including recent large-scale RCTs and assessing the quality of the pooled evidence.

Methods: We searched several databases and trial registers from inception to April 2022. We used a random-effects model to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs). We used the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considerations to evaluate the certainty of evidence.

Results: We included 13 RCTs in our study. Vitamin D supplementation had no effect on the risk of total cancer incidence (RR 0.99, 95% CI: 0.94-1.04; I 2 = 0%), total cancer mortality (RR 0.93, 95% CI: 0.84-1.03; I 2 = 24%) and total mortality (RR 0.92, 95% CI: 0.82-1.04; I 2 = 36%). The overall quality of evidence was high for all outcomes.

Discussion: Vitamin D supplementation is ineffective in reducing total cancer incidence and mortality in largely vitamin D-replete older adult populations. Future research should be based on populations with a higher prevalence of vitamin D deficiency and should involve more extended follow-up periods.

Study protocol: PROSPERO database, CRD42021285401.

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Similar meta-analysis: only 2 studies used > 3,000 IU daily ==> 4X reduction in mortality - March 2023

Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials

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VitaminDWiki Mortality pages with CANCER in the title (35 as of Nov 2022)

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Examples of successful Cancer trials: 4,000 IU, measure D levels, add Omega-3, etc.

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Tags: Cancer Mortality