Breast cancer spreads to bone if poor vitamin D Receptor (no surprise)

Vitamin D receptor expression is significantly decreased in bone metastases compared to matched primary breast cancer tumours

Cancer Invest . 2022 Oct 31;1-22. doi: 10.1080/07357907.2022.2142604 PDF is behind a paywall

Konstantin Horas 1 2 , Marc Abraham 2 , Regina Ebert 2 , Manuel Weissenberger 1 , Gerrit S Maier 3 , Franz Jakob 2 , Andreas Rosenwald 4 , Maximilian Rudert 1

There is ample evidence today that vitamin D signalling via the VDR plays a pivotal role in cancer growth and metastasis.The aim of this study was to analyse VDR expression of primary breast cancer and corresponding bone metastases tissue samples. Collectively, 15 sample pairs and 11 samples of patients that did not develop metastases were analysed histologically for VDR expression (n = 41).Overall, VDR expression was significantly lower in bsone metastases compared to primary tumour samples (p < 0.0001). Downregulation of the VDR in breast cancer cells may define a critical turning point in oncogenesis that accelerates cancer cell dissemination and metastases.

VitaminDWiki Vitamin D Receptor pages with CANCER in title (79 as of Oct 2022)

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VitaminDWiki - studies in both categories Breast Cancer and VDR

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VitaminDWiki pages with METASTATIC etc in title (9 as of Oct 2022)

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