Breast Cancer and Vitamin D review

Created March 2019

Vitamin D and Breast Cancer: Past and Present

The Journal of steroid biochemistry and molecular biology 2017;177:15-20.

JoEllen Welsh, PhD

1. Decrease Breast Cancer 3X If raise your Vitamin D blood levels 4X - 16X If increase activation of your Vitamin D Receptors Note: Breast Cancer lowers the activation of Vitamin D Receptors Overview Breast Cancer and Vitamin D contains the following summary and sections {include} Items in both categories Breast Cancer and Vitamin D Receptor are listed here: {category} --- The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019 Vitamin D Receptor table shows what compensates for low VDR activation {include}

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Table of Contents

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The presence of the vitamin D receptor in mammary gland and breast cancer has been recognized since the early 1980s, and multiple pre-clinical studies have demonstrated that its ligand 1,25D modulates normal mammary gland development and sensitivity to carcinogenesis. Although studies have characterized many 1,25D responsive targets in normal mammary cells and in breast cancers, validation of relevant targets that regulate cell cycle, apoptosis, autophagy and differentiation, particularly in vivo, has been challenging. Vitamin D deficiency is common in breast cancer patients and some evidence suggests that low vitamin D status enhances the risk for disease development or progression. Model systems of carcinogenesis have provided evidence that both VDR expression and 1,25D actions change with transformation but clinical data regarding vitamin D responsiveness of established tumors is limited and inconclusive. Because breast cancer is heterogeneous, analysis of VDR actions in specific molecular subtypes of the disease is necessary to clarify the conflicting data. Genomic, proteomic and metabolomic analyses of in vitro and in vivo model systems is also warranted to comprehensively understand the network of vitamin D regulated pathways in the context of breast cancer heterogeneity

Tags: Breast Cancer Vit D Receptor