A low Vitamin D disease, if unsupplemented, leads to many problems, e.g. death (Psoriasis in this case)

Double the risk of death if Psoraisis and low Vitamin D - Sept 2025

Associations of serum 25-hydroxyvitamin D concentrations with risks of mortality and cardiovascular disease among individuals with psoriasis

J Am Acad Dermatol 2025 Sep;93(3):678-688. doi: 10.1016/j.jaad.2025.05.1380 PDF is behind paywall

Kaiqing Lin 1, Ya Miao 1, Lu Gan 1, Bin Zhao 1, Fang Fang 2, Ru Wang 3, Xiang Chen 4, Jiaqi Huang 5

Background: Evidence remains scarce regarding the relationship between serum 25-hydroxyvitamin D (25(OH)D) and the risk of mortality and cardiovascular disease (CVD) in psoriasis.

Objective: To explore the potential protective effect of serum 25(OH)D on the risk of mortality and CVD among patients with psoriasis.

Methods: This cohort study included 8947 psoriasis patients and 178,937 controls identified at baseline in the UK Biobank cohort. Serum 25(OH)D levels were prospectively collected at the time of recruitment. Multivariable-adjusted Cox proportional hazards regression models were used to evaluate the associations between levels of serum 25(OH)D and risk of overall mortality and CVD incidence.

Results: Compared to the lowest level of serum 25(OH)D (<25 nmol/L), hazard ratios were 0.54 and 0.78 for overall mortality and incident CVD for the highest level of serum 25(OH)D (≥50 nmol/L) among psoriasis patients, respectively (all P < .05). Psoriasis patients with serum 25(OH)D ≥ 50 nmol/L appeared to have no excess risk of mortality and CVD incidence, compared with matched controls.

Limitations: Information on psoriasis subtypes was not available.

Conclusion: A higher level of serum 25(OH)D was associated with a reduced risk of overall mortality and CVD in individuals with psoriasis.

See related in VitaminDWiki

• Mortality

  People die sooner if they have low vitamin D

• More vitamin D means fewer deaths – many studies

• COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024

• Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018

• Increased mortality if low Vitamin D - US July 2025

• Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016

• Diseases that may be related via low vitamin D 92+ entries, here are some of the Psoriasis ones

  • Psoriasis ==> Metabolic Syndrome on the web

  • Psoriasis ==> Metabolic Syndrome

  • Psoriasis ==> Kidney Disease

  • Psoriasis ==> Heart problems

  • Psoriasis ==> Diabetes

  • Psoriasis==> Osteoporosis

  • Psoriasis ==> Sleep Apnea

  • Celiac Disease ==> Anemia, Psoriasis