5X more likely to test positive for COVID-19 if low vitamin D in previous 5 years (900,000 people)

Created December 2020

Increased Risk for Covid-19 in patients with Vitamin D deficiency.

Nutrition, https://doi.org/10.1016/j.nut.2020.111106

JosephKatzDMD1SijiaYueMSc2WeiXuePhD2

Data from people in Florida over a 5 year time period Some had a vitamin D deficiency billable code of E 55.9 (generally < 20 ng) "From a total population of 987,849 patients, * 887 were diagnosed with positive Covid-19, * 31,950 had a diagnosis of Vitamin D deficiency and * 87 patients had both vitamin D deficiency and Covid-19. " --- 1. In VitaminDWiki COVID-19 treated by Vitamin D - studies, reports, videos {include} One of the 34 Observational Trials * Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020 Clinical trials are proving that Vitamin D fights COVID-19 in hospitals includes {include} --- Note: VitaminDWiki guesses that if the data could be re-analyzed for those >40 ng/ml of vitamin D, that the Risk of COVID-19 would be about 20X We offered to do that re-analysis, but the author will not release the data without IRB approval - which appears to take about 20 hours of time over 4-8 weeks

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Background

: The new Covid-19 pandemic has disproportionally affected a variety of patients with underlying risk factors such as respiratory and cardiovascular diseases, diabetes, obesity, and African American race. Vitamin D deficiency that can result in compromised immune response has also been linked with increased risk and increased morbidities associated with Covid-19. In the absence of large scale longitudinal studies that can determine the strength of association between vitamin deficiency and Covid-19, cross sectional studies of large cohorts of patients can be used.

Material and methods

: We have used the i2b2 patient's registry platform at the University of Florida Health center to generate a count of patients using the ICD 10 diagnoses codes for the period of 10/1/2015 – 6/30/2020. Logistic regression of the aggregates was used for the analysis.

Results

: Patients with vitamin D deficiency were 4.6 times more likely to be Covid-19 positive, as indicated by a COV19 ICD 10 diagnostic code, than patients with no deficiency (P-value<0.001). The association decreased slightly after adjusting for gender (with OR=4.58, p<0.001) and for malabsorption (with OR=4.46, p<0.001) respectively. The association decreased significantly but remained robust with P-value<0.001 after adjusting for race (with OR=3.76, p<0.001), periodontal disease status (with OR=3.64, p<0.001), diabetes (with OR=3.28, p<0.001) and obesity (with OR=2.27, p<0.001), respectively. In addition, patients with vitamin D deficiency were 5 times more likely to be infected with Covid-19 than patients with no deficiency after adjusting for age groups ( OR=5.155 , p<0.001).

Conclusion

Vitamin D deficiency is significantly associated with increased risk for Covid-19.

Tags: Virus