2.7 fewer COVID-19 hospital deaths in those having more than 30 ng of vitamin D – Mayo

Vitamin D Status is Associated With In-hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients

Mayo Clinic Proceedings. online 9 January 2021, https://doi.org/10.1016/j.mayocp.2021.01.001

Angeliki M.AngelidiMD PhDa∗Matthew J.BelangerMDa∗Michael K.LorinskyMDaDimitriosKaramanisPhDbNataliaChamorro-ParejaMDcdJenniferOgnibeneBAcLeonidasPalaiodimosMD MSccdeChristos S.MantzorosMD DScaf

1. Note: - several studies have found that >40 ng is much better than >30 ng Suspect if this data were re-analyzed for >40 ng that 2.7X ==>10X * Vitamin D Sufficiency Reduced Risk for Morbidity and Mortality in COVID-19 Patients - Holick July 14 * * No COID19 deaths in a hospital if >41 ng and <80 years old** * * 40 ng of Vitamin D to fight COVID 15K to 50K weekly or 100K monthly - Spanish Jan 2021 --- 1. Mortality and Virus studies {category} 1. Virus meta-analyses {category} --- 1. COVID-19 treated by Vitamin D - studies, reports, videos {include}

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: Appears to be a9% decrease in mortality per each additional ng of vitamin D

Objective

To explore the possible associations of serum 25-hydroxyvitamin D concentration [25(OH)D] with COVID-19 in-hospital mortality and need for invasive mechanical ventilation.

Patients and Methods

A retrospective, observational, cohort study was conducted at two tertiary academic medical centers in Boston and New York. Eligible participants were hospitalized adult patients with laboratory-confirmed COVID-19 between 1 February 2020 and 15 May 2020. Demographic, clinical characteristics, comorbidities, medications, and disease-related outcomes were extracted from electronic medical records.

Results

The final analysis included 144 patients with confirmed COVID-19 (median age: 66 years, 44.4% male). Overall mortality was 18%, while patients with 25(OH)D levels ≥30 ng/mL had lower rates of mortality compared to those with 25(OH)D levels <30 ng/mL ( 9.2% vs. 25.3% , P=.02). In the adjusted multivariable analyses, 25(OH)D as a continuous variable was independently significantly associated with lower in-hospital mortality (OR, 0.94; 95% CI, 0.90-0.98; P=.007) and need for invasive mechanical ventilation (OR, 0.96; 95% CI, 0.93-0.99; P=.01). Similar data were obtained when 25(OH)D was studied as a continuous variable after logarithm transformation and as a dichotomous (<30ng/mL vs. ≥30ng/mL) or ordinal variable (quintiles), in the multivariable analyses.

Conclusion

Among patients admitted with laboratory-confirmed COVID-19, 25(OH)D levels were inversely associated with in-hospital mortality and the need for invasive mechanical ventilation. Further observational studies are needed to confirm these findings and randomized clinical trials to assess the role of vitamin D administration in improving the morbidity and mortality of COVID-19.

Comorbidities from PDF

74% hypertension,

55% hyperlipidemia,

43.8% diabetes mellitus type 2

14% history of coronary artery disease

13% history of cerebrovascular disease

18.1%. Asthma,

15.3%, COPD

12.5% obstructive sleep apnea

In hospital

63.9% had increased oxygen requirements,

27.1% required invasive mechanical ventilation,

39% transferred to the ICU.

47.2% acute kidney injury

11.1% required renal replacement therapy.