20,000 IU of Vitamin D weekly gave many benefits – RCT

Created January 2020

Effects of Vitamin D Supplementation on Body Composition and Metabolic Risk Factors in Men: A Randomized Controlled Trial

Nutrients 2019, 11(8), 1894; https://doi.org/10.3390/nu11081894

1. Better than Daily 1. Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has: {include} Intervention - non daily category listing has items along with related searches Items in both categories Obesity and Intervention – non daily are listed here: {category}

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by Elisabeth Lerchbaum 1,*,Christian Trummer 1,Verena Theiler-Schwetz 1,Martina Kollmann 2,Monika Wölfler 2,Stefan Pilz 1 andBarbara Obermayer-Pietsch 1

  • 1 Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria

  • 2 Division of Obstetrics, Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14/1, 8036 Graz, Austria

Vitamin D might play a role in metabolic processes and obesity. We therefore examined vitamin D effects on metabolic markers and obesity in a randomized controlled trial (RCT). This is a post-hoc analysis of the Graz Vitamin D&TT-RCT;, a single-center, double-blind, randomized placebo-controlled trial. We included 200 healthy men with serum 25-hydroxyvitamin D (25(OH) D) levels <75 nmol/L.

Subjects received 20,000 IU of vitamin D3/week (n = 100) or placebo (n = 100) for 12 weeks.

Outcome measures were metabolic markers, anthropometric measures, and body composition assessed by Dual-energy X-ray absorptiometry. One-hundred and ninety-two men completed the study. We found a significant treatment effect on

  • fasting glucose/fasting insulin ratio (−5.3 (−10.4 to −0.2), p = 0.040),

whereas we observed no significant effect on the remaining outcome parameters.

In subgroup analyses of men with baseline 25(OH)D levels <50 nmol/L (n = 80), we found a significant effect on

  • waist circumference (1.6 (0.3 to 2.9) cm, p = 0.012),

  • waist-to-hip ratio (0.019 (0.002 to 0.036), p = 0.031),

  • total body fat (0.029 (0.004 to 0.055) %, p = 0.026), and

  • android fat (1.18 (0.11 to 2.26) %, p = 0.010).

In middle-aged healthy men, vitamin D treatment had a negative effect on insulin sensitivity.

In vitamin D deficient men, vitamin D has an unfavorable effect on central obesity and body composition.