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Vitamin D2 treatment reduced the Vitamin D3 blood test results by half – Feb 2012

Effect of treatment with 50,000 IU Vitamin D2 every other week on serum 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and total 25-hydroxyvitamin D in a clinical setting.

Endocr Pract. 2012 Feb 20:1-12.
Demetriou ET, Travison TG, Holick MF.
Section of Endocrinology and Diabetes, Maine Medical Center, Portland, ME 04101.

Context: It has been reported that vitamin D2 supplements are less effective than vitamin D3 and that vitamin D2 supplements may increase the degradation of serum 25-hydroxyvitamin D3 [25(OH)D3.]

Objective: Our objective was to examine the effect of 50,000 IU vitamin D2 supplementation in a clinical setting on serum total 25-hydroxyvitamin D [25(OH)D], 25-hydroxyvitamin D2 [25(OH)D2] and 25(OH)D3.

Methods: This is a retrospective cohort study performed in an urban tertiary referral hospital in Boston, Massachusetts.
48 patients who had been started on 50,000 IU vitamin D2 repletion and maintenance programs were identified through a search of our electronic medical record.
Baseline and follow-up total serum 25(OH)D, 25(OH)D2 and 25(OH)D3 were compared.

Results: The mean baseline total 25(OH)D was 31.0 ± 10.6 ng/ml and rose to 48.3 ± 13.4 ng/ml after treatment (p=<0.001).
25(OH)D2 increased from 4.2 ± 4.3 ng/ml to 34.6 ± 12.3 ng/ml after treatment (p<0.001) for an average of 158 days (range 35-735).
Serum 25(OH)D3 decreased from 26.8 ± 10.8 ng/ml to 13.7 ± 7.9 g/ml (p<0.001).

Conclusions: 50,000IU vitamin D2 repletion and maintenance therapy substantially increased total 25(OH)D and 25(OH)D2 despite a decrease in serum 25(OH)D3.
This treatment program is an appropriate and effective strategy to treat and prevent vitamin D deficiency.

PMID: 22440989
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Summary: Vitamin D Blood levels dropped from 27 ng to 14 ng after treatment with Vitamin D2

See also VitaminDWiki

Overview Vitamin D3 not D2 which has the following graphs

Far better response to D3 than D2

Response to 20,000 IU vitamin D3 extra per week


Most > 20ng and some > 40ng

Response to 20,000 IU of vitamin D2 per week (im = inter-muscular injection)


Very few got to 40ng