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Vitamin D might help critically ill patients (if enough is given quickly) – Nov 2022


Vitamin D Status and Potential Therapeutic Options in Critically Ill Patients: A Narrative Review of the Clinical Evidence

Diagnostics 2022, 12(11), 2719; https://doi.org/10.3390/diagnostics12112719
Cutuli, S.L.; Cascarano, L.; Tanzarella, E.S.; Lombardi, G.; Carelli, S.; Pintaudi, G.; Grieco, D.L.; De Pascale, G.; Antonelli, M.

Vitamin D covers roles of paramount importance in the regulation of multiple physiological pathways of the organism. The metabolism of vitamin D involves kidney–liver crosstalk and requires an adequate function of these organs, where vitamin D is progressively turned into active forms. Vitamin D deficiency has been widely reported in patients living in the community, being prevalent among the most vulnerable subjects. It has been also documented in many critically ill patients upon admission to the intensive care unit. In this context, vitamin D deficiency may represent a risk factor for the development of life-threatening clinical conditions (e.g., infection and sepsis) and worse clinical outcomes. Several researchers have investigated the impact of vitamin D supplementation showing its feasibility, safety, and effectiveness, although conflicting results have put into question its real benefit in critically ill patients. The existing studies included heterogeneous critically ill populations and used slightly different protocols of vitamin D supplementation. For these reasons, pooling up the results is difficult and not conclusive.
In this narrative review, we described vitamin D physiology and the pathophysiology of vitamin D depletion with a specific focus on critically ill patients with

  • liver dysfunction,
  • acute kidney injury,
  • acute respiratory failure, and
  • sepsis.

 Download the PDF from VitaminDWiki


This study incorrectly assumes that 30 ng of Vitamin D is sufficient for the critical ill, but fails to say levels achieved
Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
Fertility
Psoriasis
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors


VitaminDWiki - Sepsis is both prevented and treated by Vitamin D - many studies contains

  • Sepsis is more likely in those with poor immune systems
    Infants, the elderly, the sick, and those with low vitamin D
  • Severe sepsis has been associated with low Vitamin D and poor Vitamin D receptor in many studies
  • Loading doses of Vitamin D bypass any poor Vitamin D Receptors
  • Vitamin D loading doses have been proven to treat sepsis (RCTs: 2015, 2020, 2021)
      Reduced: ICU stay by 8 days, Hospital stay by 7 days, and readmission rate reduced to 0%
      Note: The fastest way (2 hours) to have a sublingual loading dose of Vitamin D nano-emulsion
  • Sepsis is fought by Vitamin D in 9 ways – Feb 2023
  • Image

VitaminDWiki - 35 studies in both categories Trauma-Surgery and Loading Dose

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Created by admin. Last Modification: Tuesday November 8, 2022 01:39:39 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
18783 Potential Criticall Ill_CompressPdf.pdf admin 08 Nov, 2022 321.36 Kb 78