Vitamin D may influence pain intensity – review Nov 2024

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Relationship Between Serum Vitamin D Levels and Chronic Musculoskeletal Pain in Adults: A Systematic Review

Nutrients 2024, 16(23), 4061; https://doi.org/10.3390/nu16234061
by José Luís Alonso-Pérez 1,2ORCID,Iker Martínez-Pérez 1,Carlos Romero-Morales 1ORCID,Vanesa Abuín-Porras 1ORCID,Ruben López-Bueno 3,4,5ORCID,Giacomo Rossettini 1,*ORCID,Massimiliano Leigheb 6,† and Jorge Hugo Villafañe 1,2,*,†ORCID

Background/Objectives: Chronic pain impacts approximately 18% of the Spanish population, with low levels of vitamin D prevalent in over 80% of individuals over 65. Given vitamin D’s critical role in pain modulation, its deficiency may be significantly linked to chronic musculoskeletal pain, though existing research offers mixed results.

Methods: This systematic review followed PRISMA guidelines, examining studies from PubMed, Cochrane, and PEDRO databases from 1990 onwards that investigated the relationship between vitamin D levels and chronic musculoskeletal pain.

Results: A total of 30 studies met the inclusion criteria set by the NHLBI’s quality standards. The results are inconclusive regarding the direct relationship between vitamin D levels and chronic musculoskeletal pain due to evidence heterogeneity. However, there appears to be an inverse relationship between vitamin D levels and the intensity of pain.

Conclusions: While the association between vitamin D levels and chronic musculoskeletal pain remains uncertain, the inverse correlation with pain intensity suggests a potential therapeutic role of vitamin D supplementation in pain management. Further research is needed to substantiate these findings and refine intervention strategies.
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VitaminDWiki – Pain - chronic category contains:

168 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Percentage of people with pain increased 25 percent in 18 years – Jan 2019
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 82 items
• "musculoskeletal pain" 490 items as of Aug 2023
• "chronic fatigue" 240 items have it in title or abstract as of Dec 2024
• Category Back Pain 44 items
• 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
• Opioid OR Opiate OR Morphine in the title 14 pages as of Dec 2024