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Vitamin D less than 15 ng associated with some allergies – Feb 2011

Vitamin D levels and food and environmental allergies in the United States: Results from the National Health and Nutrition Examination Survey 2005-2006.
J Allergy Clin Immunol. 2011 Feb 15.
Sharief S, Jariwala S, Kumar J, Muntner P, Melamed ML.
Department of Medicine, Rush University Medical Center, Chicago.

BACKGROUND: Previous research supports a possible link between low vitamin D levels and atopic disease. However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied.

OBJECTIVE: We sought to test the association between serum 25-hydroxyvitamin D (25OHD) deficiency (<15 ng/mL) and insufficiency (15-29 ng/mL) and allergic sensitization measured by serum IgE levels in a US nationally representative sample of 3136 children and adolescents and 3454 adults in the National Health and Nutrition Examination Survey 2005-2006.

METHODS: The association of 25(OH)D deficiency with 17 different allergens was assessed after adjustment for potential confounders, including age; sex; race/ethnicity; obesity, low socioeconomic status; frequency of milk intake; daily hours spent watching television, playing videogames, or using a computer; serum cotinine levels; and vitamin D supplement use.

RESULTS: In children and adolescents allergic sensitization to 11 of 17 allergens was more common in those with 25(OH)D deficiency. Compared with sufficient vitamin D levels of greater than 30 ng/mL, after multivariate adjustment, 25(OH)D levels of less than 15 ng/mL were associated with
peanut (odds ratio OR, 2.39; 95% CI, 1.29-4.45),
ragweed (OR, 1.83; 95% CI, 1.20-2.80), and
oak (OR, 4.75; 95% CI, 1.53-4.94) allergies (P < .01 for all).

Eight other allergens were associated with 25(OH)D deficiency, with P values of less than .05 but greater than .01.
There were no consistent associations seen between 25(OH)D levels and allergic sensitization in adults.

CONCLUSION: Vitamin D deficiency is associated with higher levels of IgE sensitization in children and adolescents.
Further research is needed to confirm these findings.
Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. PMID: 21329969
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