Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – Feb 2023

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Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?

Reviews in Endocrine and Metabolic Disorders https://doi.org/10.1007/s11154-023-09792-7
Andrea Giustina1,2 • Luigi di Filippo1 • Agnese Allora1 • Daniel D. Bikle3 • Giulia Martina Cavestro4 •
David Feldman5 • Giovanni Latella6 • Salvatore Minisola7 • Nicola Napoli8 • Silvia Trasciatti9 • Melin Uygur1,10 •

PDF Table of Contents

This paper is one of the outcomes of the 5 th International Conference "Controversies in Vitamin D" held in Stresa, Italy from 15 to 18 September 2021 as part of a series of annual meetings which was started in 2017. The scope of these meetings is to discuss controversial issues about vitamin D. Publication of the outcomes of the meeting in international journals allows a wide sharing of the most recent data with the medical and academic community. Vitamin D and malabsorptive gastrointestinal conditions was one of the topics discussed at the meeting and focus of this paper. Participants to the meeting were invited to review available literature on selected issues related to vitamin D and gastrointestinal system and to present their topic to all participants with the aim to initiate a discussion on the main outcomes of which are reported in this document. The presentations were focused on the possible bidirectional relationship between vitamin D and gastrointestinal malabsorptive conditions such as celiac disease, inflammatory bowel diseases (IBDs) and bariatric surgery. In fact, on one hand the impact of these conditions on vitamin D status was examined and on the other hand the possible role of hypovitaminosis D on pathophysiology and clinical course of these conditions was also evaluated. All examined malabsorptive conditions severely impair vitamin D status. Since vitamin D has known positive effects on bone this in turn may contribute to negative skeletal outcomes including reduced bone mineral density, and increased risk of fracture which may be mitigated by vitamin D supplementation. Due to the immune and metabolic extra-skeletal effects there is the possibility that low levels of vitamin D may negatively impact on the underlying gastrointestinal conditions worsening its clinical course or counteracting the effect of treatment. Therefore, vitamin D status assessment and supplementation should be routinely considered in all patients affected by these conditions. This concept is strengthened by the existence of a possible bidirectional relationship through which poor vitamin D status may negatively impact on clinical course of underlying disease. Sufficient elements are available to estimate the desired threshold vitamin D level above which a favourable impact on the skeleton in these conditions may be obtained. On the other hand, ad hoc controlled clinical trials are needed to better define this threshold for obtaining a positive effect of vitamin D supplementation on occurrence and clinical course of malabsorptive gastrointestinal diseases.
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8+ VitaminDWiki pages with CELIAC in title

This list is automatically updated

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28+ VitaminDWiki pages with IBD in title

This list is automatically updated

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12+ VitaminDWiki pages with BARIATRIC in title

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VitaminDWiki – Overview Gut and vitamin D has

• Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
• Celiac disease has a strong genetic component.
  • Most, but not all, people with celiac disease have a gene variant.
  • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
  • Celiac disease causes poor absorption of nutrients such as vitamin D.
  • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
  • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
• Review in Nov 2013 found that Vitamin D helped
  Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
• All items in category gut and vitamin D 191 items

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VitaminDWiki – Overview Gut and vitamin D contains gut-friendly information__

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VitaminDWiki –Gut category contains

191 items in GUT category - see also Overview Gut and vitamin D,

• "Ulcerative Colitis" OR UC 839 items Jan 2020
• "celiac disease" OR CD 1830 items July 2019
• IBS or IBD or IRRITABLE BOWEL in title of 41 VitaminDWiki pages as of Aug 2022
• Gut-Friendly forms of vitamin D
  • such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .

See also Microbiome category listing has 32 items along with related searches.