Vitamin D improves Infertility in 9 ways (50 references, no PDF) – May 2023

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Vitamin D and infertility

Curr Opin Obstet Gynecol . 2023 May 22. doi: 10.1097/GCO.0000000000000887
Samantha Simpson 1, Lubna Pal 2

Purpose of review: Vitamin D deficiency has been implicated as a contributing factor to a spectrum of reproductive health burden, including

• difficulty conceiving,
• pathogenesis of gynaecological disorders such as
  • uterine fibroids and endometriosis, to
• metabolic and endocrine burden of polycystic ovarian syndrome (PCOS).

Recent findings: There have been recent publications showing that in infertile women who are supplemented with vitamin D,

• there are higher pregnancy rates;
• there are improved ovarian reserve parameters in women with diminished ovarian reserve;
• curtailed fibroid growth in those with uterine myomas;
• lessened dysmenorrhea in endometriosis patients; and
• improved menstrual regularity,
• lowered testosterone, AMH and insulin levels in women with PCOS.

In infertile men, sperm parameters, especially motility, are positively correlated with vitamin D serum levels.

Summary: Vitamin D status appears to be relevant to reproductive physiology, and to physiological processes underlying common gynaecological disorders as well as for reproductive success.

References

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VitaminDwiki – Fertility and Sperm category contains

131 items in Fertility or Sperm in VitaminDWiki

See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" in 11 VitaminDWiki titles as of Jan 2022
Search VitaminDWiki for "Assisted reproduction" 177 items as of Sept 2019
Search VitaminDWiki for "polycystic ovary syndrome" OR PCOS" Sept 2019
Search VitaminDWiki fore Testosterone 77 items just in webpages as of Sept 2020
Search VitaminDWiki for "erectile dysfunction" 120 items as of July 2018
Conception and vitamin D snapshot as of 2012
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• Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
• Infertile patients 1.7X more-likely to become pregnant if take Vitamin D – meta-analysis Feb 2023
• Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis Aug 2020
• If diagnosed infertile, more likely to have live birth if Vitamin D fortification – Feb 2020
• Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
• In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
• Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
• Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
• Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
• IVF 4X more successful for white women with lots of vitamin D – many studies

Increased male Vitamin D increases fertility

• Conception was 3.7X more likely if the male had a good level of Vitamin D – July 2022
• Far better sperm in fertility clinic if more than 30 ng of Vitamin D - June 2022
• Fertility (sperm) associated with vitamin D – meta-analysis Sept 2019
• Infertility - 71 percent of the time of BOTH partners had less than 20 ng of Vitamin D – Aug 2017
• Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017
• Male fertility 4 X higher if high Vitamin D – Nov 2015
• Vitamin D somewhat assists reproduction – both the mother and the father – May 2014
• Male fertility is improved in many ways by vitamin D – Jan 2014

Decreased Fertility if decreased Vitamin D Receptor

• Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
• Male Infertility is associated with poor Vitamin D Receptor – July 2021