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Vitamin D helps organ transplant

Summary of many studies of Vitamin D and organ transplantation

More vitamin D needed especially needed if organ = liver or kidney (low vitamin d ==> poor bones)
Both regular and active vitamin D have been used
Supplementation can be oral, injection, etc
Extra Vitamin D can be before or after the surgery
Problems avoided include: infection, rejection, death


Vitamin D in organ transplantation - 2011

Osteoporos Int. 2011 Jan 5.
Stein EM, Shane E.
Department of Medicine, Columbia University Medical Center, 630 West 168th Street, PH8-864, New York, NY, 10032, USA, es2029 at columbia.edu.

Vitamin D deficiency is prevalent among patients with end-stage organ failure awaiting transplant. Low serum 25-hydroxyvitamin D (25-OHD) levels in these patients may be related to many disease-specific factors, as well as decreased sunlight exposure and limited intake of foods containing vitamin D.

Low serum 25-OHD levels are also extremely common following solid organ transplantation, both during the immediate postoperative period and in long-term graft recipients.

Demographic and lifestyle factors are important in determining D status in transplant recipients.

Worse vitamin D status is associated with poorer general health, lower albumin, and even decreased survival among these patients.

Although several studies have demonstrated that active forms of vitamin D and its analogues prevent bone loss following transplantation, the data do not show consistent benefit.

These therapies may have particular utility after renal transplantation. However, given the narrow therapeutic window with respect to hypercalcemia and hypercalciuria, and the demonstrated efficacy of bisphosphonates to prevent post-transplantation bone loss, we regard these agents as adjunctive rather than primary therapy for transplantation osteoporosis.

The effects of 1,25(OH)(2)D on the immune system, which are still being elucidated, may have potential for reducing infections and preventing allograft rejection after transplantation. PMID: 21207011


Survive heart transplant better if have more vitamin D

Image

PDF is attached at the bottom of this page PDF was public domain in Dec 2012
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Attached files

ID Name Comment Uploaded Size Downloads
1887 Heart Transplant survival vs calcitriol.jpg admin 28 Dec, 2012 16:08 24.26 Kb 1036
1886 Vitamin D in organ transplantation.pdf PDF admin 28 Dec, 2012 16:03 326.33 Kb 606
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