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Vitamin D given for 6 weeks did not slow prediabetes progression 2 years later (no surprise) – RCT Aug 2021

A community based randomized controlled trial to see the effect of vitamin d supplementation on development of diabetes among women with prediabetes residing in a rural community of Northern India

J Family Med Prim Care 2021;10:3122-9DOI: 10.4103/jfmpc.jfmpc_311_21
Puneet Misra1, Shashi Kant1, Anoop Misra2, Shreya Jha1, Priyanka Kardam1, Nishakar Thakur1, Surya P Bhatt3
1 Centre for Community Medicine, AIIMS, New Delhi, India
2 Fortis C-DOC Center of Excellence for Diabetes, Metabolic Diseases, and Endocrinology, New Delhi, India
3 Department of Sleep and Pulmonary Medicine, AIIMS, New Delhi, India


Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 529 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 34;  Pregnancy 43;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 23;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies

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Background: The primary objective of this study was to intervene with vitamin D supplementation in rural-based women with pre-diabetes (impaired fasting glucose or impaired glucose tolerance) to prevent development of type 2 diabetes (T2DM).

Methods: This was an open-label randomized placebo-controlled trial conducted in rural women with pre-diabetes and vitamin D deficiency (Clinicaltrials.gov NCT02513888). Women aged 20-60 years with pre-diabetes were selected from rural Haryana (north India) and followed up for two years. A semi-structured questionnaire was used to collect information on socio-demographic and behavioral details, like sun exposure, dietary habits, etc., The intervention group received vitamin D supplementation while control group received lactose granules as placebo. Equal doses of calcium carbonate were given to both the groups.

Results: A total of 132 participants were recruited in the study (58 each in the intervention and control groups). It was observed that there was no statistical significance in the incidence of diabetes in the control group as compared to the intervention group at the end of 2 years (P = 0.701).

Conclusion: Though during the first year there was some delay in development of DM in the intervention group but at the end of two years there was no significant effect of vitamin D supplementation in delaying the incidence of diabetes in these women after two years. Trial registration: (Clinicaltrials.gov NCT02513888).

Created by admin. Last Modification: Friday August 27, 2021 18:23:42 GMT-0000 by admin. (Version 1)