Toggle Health Problems and D

Vitamin D associated with 60 percent better assisted reproductive success – Dec 2019

Vitamin D and assisted reproductive treatment outcome: a prospective cohort study

Reproductive Health, December 2019, 16:106
Justin ChuIoannis Gallos Aurelio Tobias Lynne Robinson Jackson Kirkman-Brown Rima Dhillon-Smith Hoda Harb Abey Eapen Madhurima Rajkhowa Arri Coomarasamy

 Download the PDF from VitaminDWiki

Vitamin D deficiency has been associated with an increased risk of abnormal pregnancy implantation leading to obstetric complications such as pre-eclampsia and fetal growth restriction. However, the effect of vitamin D on reproductive treatment outcomes in couples undergoing assisted reproductive treatment is poorly understood. This study investigates the association between vitamin D and reproductive treatment outcomes in women undergoing assisted reproductive treatments?

A prospective cohort study conducted at a large tertiary teaching hospital, United Kingdom. Five hundred women undergoing assisted reproductive treatment were recruited between September 2013 and September 2015. All participants had their serum vitamin D measured and their reproductive treatment outcomes collated. Women were categorised in to three groups: vitamin D replete (> 75 nmol/L), insufficient (50-75 nmol/L) and deficient (< 50 nmol/L) according to Endocrine Society guidance. The primary outcome was live birth. Secondary outcomes included biochemical pregnancy, clinical pregnancy and pregnancy loss rates.

Vitamin D deficiency was found in 53.2% (266/500) of participants and vitamin D insufficiency was found in 30.8% (154/500) of participants. Only 16% (80/500) of women were vitamin D replete. The live birth rates for vitamin D deficient, insufficient and replete women were 23.2% (57/246), 27.0% (38/141) and 37.7% (29/77) respectively (p = 0.04). The respective live birth rates for vitamin D deficient, insufficient and replete women were 24.3, 27.1, 34.4% after adjustment for key prognostic factors (p = 0.25).

Vitamin D deficiency and insufficiency are common in women undergoing assisted reproductive treatments. The crude live birth rate achieved in women undergoing assisted reproductive treatments are associated with serum vitamin D, although statistical significance is lost when adjusting for important prognostic variables. Vitamin D deficiency could be an important condition to treat in women considering fertility treatment. A research trial to investigate the benefits of vitamin D deficiency treatment would test this hypothesis.

Created by admin. Last Modification: Saturday September 28, 2019 16:50:43 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12690 Vit D helps conception.jpg admin 28 Sep, 2019 00:22 39.40 Kb 235
12689 Vitamin D and assisted reproductive treatment outcome.pdf PDF 2019 admin 28 Sep, 2019 00:02 1.50 Mb 242
See any problem with this page? Report it (FINALLY WORKS)