High serum levels of 25-hydroxyvitamin D are associated with better quality-of-life, and lower levels of perceived stress, depression, and fatigue among breast cancer survivors
Chi-Chen Hong1, Song Yao1, Yali Zhang1, Shicha Kumar1, and Christine Ambrosone1
1Roswell Park Cancer Institute
Oral Presentation at Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX
- Higher quality of life associated with higher levels of vitamin D
- Increased Quality of Life with increased vitamin D – April 2014
- Mental stress, physical stress associations with low vitamin D
- Search VitaminDWiki for "QUALITY OF LIFE" 472 hits as of May 2015
- Overview Breast Cancer and Vitamin D contains the following summary and sections
Breast cancer worse for black women – Sept 2011
Vitamin D receptor in breasts and breast cancer vary with race – March 2013
Genes may account for some of AA Breast Cancer – April 2012
Breast cancer more deadly for blacks than whites
Hypothesis: Blacks get more cancer than whites due to lower levels of vitamin D – June 2012
Overview Dark Skin and Vitamin D
Differences in black and non-black mortality and vitamin D – Oct 2012
Overview Vitamin D Dose-Response
Many hints that vitamin D megadoses cure some diseases
Dose response equations for Vitamin D
Overview Loading of vitamin D
Overview Toxicity of vitamin D hard to overdose
How you might double your response to vitamin D
Hypothesis: increased breast cancer if not enough magnesium – Sept 2010
Hypothesis – anticancer benefits from synergy of omega-3 and vitamin D – May 2011
Hypothesis: Premenopausal Iron deficiency causes increased recurrence of breast cancer – 2008
Vitamin D3 for Vegans
Quantum dots should deliver active vitamin D directly to inflammatory breast cancer tumors – Feb 2013
Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011
Forms of vitamin D: not have to take pills, poor digestion, etc.
The sun appears better at reducing incidence of some cancers than vitamin D – Dec 2012
Less UV: 2X more breast cancer – June 2011
More Cancer, less Solar Radiation - 1941
Need lots of UV AND vitamin D to reduce risk of breast cancer – Jan 2011
Vitamin D, Sunlight and Cancer Connection – Holick Jan 2013
Solar UVB reduces Cancer Risk – Grant, Jan 2013
More UVB is associated with less cancer – study of 450,000 people – April 2012
Photodynamic therapy for Cancer might be helped by vitamin D – July 2012
A review of the evidence regarding the solar ultraviolet-B-vitamin D-cancer hypothesis - Oct 2012
How you can get more UV without getting too hot in the sun
How you can get more UV without exposing too much skin to the sun
Obesity, trauma, major health problem
Not get much D from the sun: Dark Skin, Shut-in, Far from equator
Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
County with 20 pcnt higher breast cancer rate has 2X more modified vitamin D receptor – July 2012
Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
Genes breast cancer and vitamin D receptor - Sept 2010
CYP24A1 gene in cancer cells may actually deactivate vitamin D – Oct 2012
Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012
Overview Cancer and vitamin D
Metastatic Cancer is maybe reduced by vitamin D - 5 articles
How Vitamin D prevents many cancers (c-MYC) – Nov 2012
Vitamin D and cancer: a view based of all models – April 2012
Advanced stage cancer 3X more likely if low level of vitamin D – March 2012
Possible ways that vitamin D does its magic
From Oct 2015 newsletter
In 2005, when I had breast cancer, I learned many things. I truly came to understand that one of the biggest things one faces with a serious disease is a challenge to one's values. At the beginning, when diagnosed with a stage 3 tumor, 2.5 inches in diameter (yes, 2.5 inches), the oncologist said, "of course, you'll do surgery, chemo and radiation."
Value test #2: During the 2nd round of chemo treatment, I had Paclitaxel which can create a very painful neuropathy, in my case, in the legs and feet. This was extremely debilitating and painful to me. I finally felt "NO! I will not allow this VIOLENCE against my body to continue." The value was non-violence, a very strongly held one. Little did I realize it applied to treatment of my own body.
Value test #3: During radiation, there is definitely scattering of the beams and even though they are more targeted than in the past, there is significant impact on the thyroid (mine is gone), the heart and lung. During one session, I was bleeding from my chest (due to the burning) and again, told the radiologist I would do no more treatments. He was more reasonable, but still wanted me to continue. I did not.
These values are what led to the establishment of GrassrootsHealth - and, are what leads us to ask you to help us change the game, to change the questions from drug related solutions to the things we can do with appropriate nutrition (a big player, of course, is vitamin D) and actions.
- Flaxseed Can Prevent And Kill Breast Cancer, Meta-Analysis Reveals GreenMedInfo Sept 2013
Observational studies: Lowered mortality among breast cancer patients by 32%
- Mammography Is Harmful & Should Be Abandoned, Review Concludes Sept 2015
"I believe that if screening had been a drug, it would have been withdrawn from the market long ago."
Mammography screening has been promoted to the public with three simple promises that all appear to be wrong: It saves lives and breasts by catching the cancers early.. . . "
- This Year’s Mammogram Month Launched With Devastating Report on Harms and Lack of Effectiveness Mercola Oct 2016
"1 in 1,000 Women Is Saved by Regular Mammogram Screening While 10 Undergo Cancer Treatment for No Reason"
Short url = http://is.gd/vitdbc
Background: Recent evidence suggests a role for vitamin D in breast cancer etiology and survival. Although data are not definitive, breast cancer survivors might derive additional benefits from adequate vitamin D levels, including better quality-of-life (QoL) and psychosocial well-being.
Objective: Using a prospective study design, we examined associations between QoL and psychosocial functioning among breast cancer survivors and circulating 25(OH)D levels at the time of initial breast cancer diagnosis and 1 year post diagnosis.
Methods: Women (n=504) with incident breast cancer (stages 0-III) were recruited prior to initiating breast cancer treatment at Roswell Park Cancer Institute (RPCI), with 372 patients also providing data 1 year later. Demographic and clinical data were obtained from the RPCI Surgical Oncology Breast Database. At each time point, participants provided blood samples and completed surveys on mental and physical health (SF36 Health Survey), perceived stress (Perceived Stress Scale), depression (Center for Epidemiologic Studies Depression Scale), and their experiences with fatigue (Multidimensional Assessment of Fatigue Scale). Serum 25(OH)D levels were measured by immunochemiluminometric assays.
Results: Median 25(OH)D levels at diagnosis and 1 year post were 23.8 ng/ml (range 0.1-67.4) and 26.6 ng/ml (range 3.0 – 80.0), respectively. At the time of diagnosis, multivariate logistic regression analyses indicated that women with sufficient levels of 25(OH)D (≥ 30 ng/ml) had *∼50% lower odds of reporting poor physical health (OR=0.52, 95% CI: 0.29, 0.90) or
- poor mental functioning (OR=0.54, 95% CI: 0.31, 0.95) compared to women with deficient levels (<20 ng/ml).
Women with higher 25(OH)D were also
- less likely to report high levels (>median) of perceived stress (OR=0.45, 95% CI: 0.26-0.80), depression (OR=0.46, 95% CI: 0.25-0.83)
- or fatigue (OR=0.54, 95% CI: 0.31, 0.92).
Findings were similar 1 year later, with reduced odds of poor physical health (OR=0.47, 95% CI: 0.24-0.93), poor mental health (OR=0.62, 95% CI: 0.33, 1.13), high levels of perceived stress (OR=0.67, 95% CI: 0.36, 1.25), depression (OR=0.33, 95% CI: 0.15, 0.71), and fatigue (OR=0.45, 95% CI: 0.24, 0.84).
Changes in vitamin D levels over the 1 year period were also assessed. While none of the relationships were significant, women in the upper tertile of vitamin D change (>3.99 ng/ml) were more likely to report low mental health and higher levels of perceived stress at 1 year compared to patients with declines in 25(OH)D of >0.95 ng/ml, but were less likely to report poor physical health or fatigue. This may have been due, in part, to women being somewhat more likely to use vitamin D supplements if they reported lower mental health QoL scores. Changes in circulating 25(OH)D levels during this 1 year period were strongly associated with use of supplements (p=0.001).
Conclusions: Breast cancer survivors with adequate vitamin D levels were less likely to report poor QoL compared to women with deficient vitamin D levels. Maintenance of optimal vitamin D levels may help improve breast cancer patients’ QoL as they go through breast cancer treatment.