Nutrients 2018, 10(4), 496; doi:10.3390/nu10040496
(This article belongs to the Special Issue Changing Times for Vitamin D and Health)
- Weekly dosing of vitamin D is far better than single large dose (chronic liver, children) – March 2018
Weekly dosing is looking very promising for many health problems - April 2018 - Liver, Liver Cancer, and Vitamin D – Feb 2018
- NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017
Not Vitamin D monotherapy
Items in both categories Liver and Intervention are listed here: give vitamin D and see what happens
- NAFLD and Vitamin D - many studies
- NAFLD not reduced by 1680 IU of vitamin D plus Omega-3 (no surprise) – RCT Jan 2022
- 450,000 IU of vitamin D over 9 weeks given to 100,000 teenage Iranian girls helped their livers – Feb 2019
- NAFLD is treated by Vitamin D, Omega-3, Curcumin, Silymarinm, etc. Aug 2018
- Alcoholic liver cirrhosis treated by 1,000 IU of vitamin D – July 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- Weekly dosing of vitamin D is far better than single large dose (chronic liver, children) – March 2018
- NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Non-Alcoholic Fatty Liver Disease (NAFLD) treated by Vitamin D (20,000 IU weekly after loading dose) – RCT June 2016
- Non-alcoholic fatty liver disease (NAFLD) reduced somewhat by 50,000 IU vitamin D every 2 weeks – RCT Sept 2014
- 400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015
- Vitamin D prevents Hepatitis-C and helps treat it (many studies)
Items in both categories Liver and Meta-analysis are listed here: summary of trials
- NAFLD associated with low vitamin D (in children too) – meta-analysis Aug 2019
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
- Non-Alcoholic Fatty Liver Disease treated by Omega-3 – three meta-analysis 2016-2017
- NAFLD weakly associated with low vitamin D – meta-analysis 2013
Download the PDF from VitaminDWiki
Table 1. Potential direct and indirect mechanisms of effect of vitamin D in liver diseases.
Table 2. Selected intervention studies in liver disease and study parameters
Jeremy T. Keane 1, Harendran Elangovan 2, Rebecca A. Stokes 1,2 and Jenny E. Gunton 1,2,3,
- 1 Centre for Diabetes, Obesity & Endocrinology, The Westmead Institute for Medical Research (WIMR), Westmead, Sydney, NSW 2145, Australia
- 2 The Garvan Institute of Medical Research, The University of New South Wales (UNSW), Darlinghurst, Sydney, NSW 2010, Australia
- 3 Faculty of Medicine and Health, The University of Sydney, Westmead Hospital, Westmead, Sydney, NSW 2145, Australia
Vitamin D is becoming increasingly accepted as an important physiological regulator outside of its classical role in skeletal homeostasis. A growing body of evidence connects vitamin D with hepatic disease. This review summarises the role of vitamin D in liver homeostasis and disease and discusses the therapeutic potential of vitamin D-based treatments to protect against hepatic disease progression and to improve response to treatment. While pre-clinical experimental data is promising, clinical trials around liver diseases have mostly been under-powered, and further studies will be required to clarify whether vitamin D or vitamin D analogues have beneficial effects on liver disease.