Vitamin D activation is mainly done by the tissues, not the Liver and Kidneys

Speculation of the full activation of Vitamin D by the tissues has ranged from 50% up to 90%
Many charts of Vitamin D activation only show the liver & Kidney, and ignore activation by tissues

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85% activation by Tissues – 2011

New vitamin D analogs and changing therapeutic paradigms
Kidney Int. 2011 Apr;79(7):702-7. doi: 10.1038/ki.2010.387
Cunningham J1, Zehnder D.
Centre for Nephrology, UCL Medical School, Royal Free Campus, London, UK. drjohncunningham at googlemail.com
 Download the PDF from VitaminDWiki

Vitamin D compounds have been used successfully to treat secondary hyperparathyroidism for almost three decades. Side effects of increased levels of serum calcium and phosphate and potential complications have increasingly been recognized as problematic, and this has become an even more difficult clinical challenge with the desire to capitalize on some of the pleiotropic effects of vitamin D. Nonclassical nuclear vitamin D receptor (VDR) effects on the cardiovascular system, kidneys, and immune system, with the prospect of improved patient survival, have moved to center stage. Selective vitamin D compounds with minimal effects on mineral metabolism and with maximal cardiovascular and renal benefits are now needed. New vitamin D compounds already in clinical use, which have an improved side-effect profile and differential nonclassical effects compared with calcitriol, are limited to the three licensed pharmaceuticals: paricalcitol, 22-oxacalcitriol, and doxercalciferol. Other compounds are under early development and it is anticipated that these novel therapeutic concepts will result in new vitamin D therapies that will help to reduce the high mortality rate patients with kidney disease experience.
74 citations of this study as of July 2023

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2 Activation paths have some different genes

Genetics category listing contains the following

332 articles in the Genetics category

see also

• Vitamin D Receptor has 513 items
• Vitamin D Binding Protein = GC has 176 items
• CYP27B1 has 60 items
• CYP24A1 in title of 34+ items
• CYP2R1 25+ items
• Calcidiol has 46 items
• Calcitriol has 56 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your body
• 

Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
  • However, test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family

    especially if it is one of 51+ diseases related to Vitamin D Receptor

+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase) +3) DNA and VDR tests - 120 to 200 dollars $100 to $250 +4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)

   Genes are good, have enough Magnesium, etc.

+4) Back Pain

   probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc

• The founder of VitaminDWiki took action with clues #3&4

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See also VitaminDWiki

• Fully-activated Vitamin D (Calcitriol) is produced inside and outside of the kidneys – July 2020
• Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016
• The eyes can also activate vitamin D – Feb 2014
• Vitamin D can be activated in the skin – Sept 2011
• Macrophages (a white blood cell) can activate Vitamin D without the kidneys– Sept 2021
• PhD Dissertation - Local production of active vitamin D inhibits Prostate Cancer – Oct 2012
• Kidney not essential for Vitamin D3 activation – fungi can do it – Jan 2014
• Bones can activate vitamin D – July 2013
• Perhaps even mitochondria can activate vitamin D – April 2013
• Itchy skin (pruritus) due to kidney disease was treated with topical vitamin D – April 2015
• Topical Vitamin D