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Vitamin D activation is mainly done by the tissues, not the Kidneys

Speculation of the full activation of Vitamin D by the tissues has ranged from 50% up to 90%
Many charts of Vitamin D activation only show the liver & Kidney, and ignore activation by tissues


85% activation by Tissues – 2011

New vitamin D analogs and changing therapeutic paradigms.
Kidney Int. 2011 Apr;79(7):702-7. doi: 10.1038/ki.2010.387. Epub 2010 Oct 20.
Cunningham J1, Zehnder D.
Centre for Nephrology, UCL Medical School, Royal Free Campus, London, UK. drjohncunningham at googlemail.com
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Vitamin D compounds have been used successfully to treat secondary hyperparathyroidism for almost three decades. Side effects of increased levels of serum calcium and phosphate and potential complications have increasingly been recognized as problematic, and this has become an even more difficult clinical challenge with the desire to capitalize on some of the pleiotropic effects of vitamin D. Nonclassical nuclear vitamin D receptor (VDR) effects on the cardiovascular system, kidneys, and immune system, with the prospect of improved patient survival, have moved to center stage. Selective vitamin D compounds with minimal effects on mineral metabolism and with maximal cardiovascular and renal benefits are now needed. New vitamin D compounds already in clinical use, which have an improved side-effect profile and differential nonclassical effects compared with calcitriol, are limited to the three licensed pharmaceuticals: paricalcitol, 22-oxacalcitriol, and doxercalciferol. Other compounds are under early development and it is anticipated that these novel therapeutic concepts will result in new vitamin D therapies that will help to reduce the high mortality rate patients with kidney disease experience.
__61 citations of this study as of Nov 2019


2 Activation paths have some different genes

Genetics category listing contains the following

253 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

See also VitaminDWiki

Created by admin. Last Modification: Friday November 29, 2019 12:10:55 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
13064 85 percent.jpg admin 29 Nov, 2019 00:03 42.24 Kb 26
13063 New vitamin D analogs and changing therapeutic paradigms.pdf admin 29 Nov, 2019 00:03 194.43 Kb 6
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