Items in both of the categories of Vitamin D Receptor AND Obesity
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Vitamin D Receptor and Obesity – several studies
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
Overview Obesity and Vitamin D contains the following summary
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 126 trials for vitamin D intervention of obesity as of Dec 2017
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Those with darker skins were more likely to be obese Sept 2014
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
- Obesity category has
- Normal weight Obese (50 ng = 125 nanomole)
Associations of Vitamin D Receptor Polymorphism -rs1544410 with Adiposity Phenotypes
Endocrinology & Metabolism International Journal. Volume 3 Issue 6 - 2016
Elham Sharif1, Nuha Swaidan1, Samar Shurbaji1 and Nasser M Rizk12*
1Department of Health Sciences, College of Health Sciences, University of Qatar, Qatar
2Department of Physiology, Mansoura University Egypt
Corresponding author: Nasser M. Rizk, Biomedical Sciences Program, Department of Health Sciences, College of Health Sciences, Qatar University, Doha, Qatar, Tel: 00974440347868; Email: Nassrizk at qu.edu.qa
Received: October 29, 2016 Published: December 16, 2016
Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas obesity prevalence is increasing dramatically, only a few studies were addressed this relation with obesity based only on body mass index. This study aimed to find the association between three different VDR polymorphisms BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) BsmI, with the adiposity phenotypes (BMI, body fat BF% and waist circumference (WC) as a marker of visceral obesity.
Method: In this study, 142 young female subjects from Qatar University were recruited. The study subjects were classified into 88 control subjects (BMI <24.9 kg/m2) with a mean age of 21.65 years and 54 overweight/obese subjects (BMI >25 kg/m2) with a mean age of 22.79 years. Blood samples and anthropometric measurements were evaluated. TaqMan assay was used to examine the genotyping of the three SNPs BsmI, ApaI, and TaqI using RT-PCR. In addition, vitamin D and insulin levels were measured using ELISA kits. The adiposity phenotypes were evaluated by anthropometric measurements of body weight, height, waist circumference and BF% were assessed by Body composition analyzer.
Results: The results showed that 80.3% of the study subjects were vitamin D insufficient/deficient. The main finding of the current study revealed that the carrier for the minor allele (A) in the BsmI of VDR have significantly higher BMI, WC and BF% values with p-values of 0.009, 0.015 and 0.04, respectively. In addition, it was found that increased WC is associated with lower (suboptimal) vitamin D level with an odds ratio of 3.12 and 95% CI of (1.01-9.63) with a p-value of 0.048.
Conclusion: The adiposity phenotype indicators including BMI, WC, and BF% were significantly associated with the minor allele (A) for BsmI (rs1544410); suggesting the possible relation of VDR polymorphism with obesity in Qatar. Vitamin D deficiency could affect the BF% in overweight and obese subjects.
Nasser M. Al-Daghri1,2,3*, Franca R. Guerini4, Omar S. Al-Attas Khalid M. Alkharfy1,2,5, Hossam M. Draz1,6, Cristina Agliardi4, Khader Mohammed1, Mara Biasin7, Mario Clerici1,4,7
1,2,3, Majed S. Alokail1,2,3, Andrea S. Costa4, Irma Saulle, 7 Abdul
1 Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia (KSA), 2 Prince Mutaib Chair for Biomarkers of Osteoporosis, College of Science, King Saud University, Riyadh, KSA,
3 Center of Excellence in Biotechnology Research, King Saud University, Riyadh, KSA,
4 Don Gnocchi Foundation, ONLUS, Milano and Universita degli Studi di Milano, Milano, Italy,
5 Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, KSA,
6 INRS-Institute Armand Frappier, University of Quebec, Laval, Quebec, Canada,
7 Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Milano, Italy
To explore the mechanisms underlying the suggested role of the vitamin D/vitamin D receptor (VDR) complex in the pathogenesis of obesity we performed genetic and immunologic analyses in obese and non-obese Saudi individuals without other concomitant chronic diseases. Genomic DNA was genotyped for gene single nucleotide polymorphisms (SNPs) of VDR by allelic discrimination in 402 obese (body mass index -BMI$30 kg/m2) and 489 non-obese (BMK30 kg/ m2) Saudis. Q-PCR analyses were performed using an ABI Prism 7000 Sequence Detection System. The inflammosome pathway was analysed by PCR, cytokines and plasma lipopolysaccaride (LPS) concentrations with ELISA assays. Results showed that the VDR SNPs rs731236 (G) (TaqI) and rs1544410 (T) (Bsm-I) minor allele polymorphisms are significantly more frequent in obese individuals (p = 0.009, b = 0.086 and p = 0.028, b = 0.072, respectively). VDR haplotypes identified are positively (GTA) (p = 0.008, b =1.560);or negatively (ACC) (p = 0.044, b = 0.766) associated with obesity and higher BMI scores. The GTA "risk" haplotype was characterized by an up-regulation of inflammosome components, a higher production of proinflammatory cytokines (p<0.05) and a lower VDR expression. Plasma LPS concentration was also increased in GTA obese individuals (p<0.05), suggesting an alteration of gut permeability leading to microbial translocation. Data herein indicate that polymorphisms affecting the vitamin D/VDR axis play a role in obesity that is associated with an ongoing degree of inflammation, possibly resulting from alterations of gut permeability and microbial translocation. These results could help the definition of VDR fingerprints that predict an increased risk of developing obesity and might contribute to the identification of novel therapeutic strategies for this metabolic condition.
Received April 13, 2014; Accepted June 13, 2014; Published July 14, 2014
Copyright: © 2014 Al-Daghri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are within the paper and its Supporting Information files.
Funding: This project has been funded by the College of Science Research Center, King Saud University, Riyadh, Saudi Arabia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
- Email: aldaghri2011 at gmail.com