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Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients 2022, 14(17), 3519; https://doi.org/10.3390/nu14173519
by Alessio Danilo Inchingolo et all

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” AND “bone”); (“quercetin” AND “bone”). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
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VitaminDWiki - 5 studies in both categories VDR and Bone

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (22 studies), Cognition (16 studies), Diabetes (22 studies), Hypertension (7 studies), Infant (18 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (30 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

VitaminDWiki pages with Vitamin D Receptor or VDR in title (400 as of Oct 2022)

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Items found: 404
Title Modified
Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018 11 Dec, 2018
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
Upper respiratory infection 15 percent more likely if poor Vitamin D receptor– Oct 2018 09 Dec, 2018
Vitamin D receptor mutations might cause hereditary vitamin D-resistant rickets – March 2015 08 Dec, 2018
Impaired Vitamin D Sensitivity (Vitamin D Receptor) – Nov 2018 02 Dec, 2018
Psoriasis risk in Caucasians is 1.3 X higher if poor Vitamin D Receptor – meta-analysis Nov 2018 27 Nov, 2018
Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018 23 Nov, 2018
Vitamin D Receptor in vitiligo skin activated by UVB – May 2018 11 Nov, 2018
Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018 10 Nov, 2018
Vitamin D Receptor – environment, genetics and epigenetics – May 2015 13 Oct, 2018
Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018 22 Sep, 2018
Many health risks associated with low Vit D or poor Vitamin D Receptor – more RCT needed – March 2018 18 Sep, 2018
Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018 02 Sep, 2018
Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018 27 Aug, 2018
Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018 25 Aug, 2018
Skin and oral wounds treated via Vitamin D Receptor and Calcium (book chapter) – Feb 2018 22 Aug, 2018
Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017 21 Aug, 2018
Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018 15 Aug, 2018
Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018 15 Aug, 2018
Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018 10 Aug, 2018
Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018 08 Aug, 2018
Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018 22 Jul, 2018
PCOS (polycystic ovary syndrome) 4 times more likely if poor Vitamin D Receptor – Dec 2015 11 Jul, 2018
Vitamin D Receptor and autoimmune diseases – Jan 2017 11 Jul, 2018
Risk of colon cancer increases in mice with no Vitamin D receptor in colon - July 2018 07 Jul, 2018
Sudden kidney infection in children was 9X more likely if poor Vitamin D receptor – July 2018 06 Jul, 2018
Autism associated with low Zinc during pregnancy (Zinc is needed by Vitamin D Receptor) – July 2018 02 Jul, 2018
Vitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors – June 2018 01 Jul, 2018
ADHD associated with both low vitamin D and poor Vitamin D receptor – May 2018 24 Jun, 2018
Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018 23 Jun, 2018
Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018 16 Jun, 2018
Vitamin D Receptor Signaling and Cancer – Dec 2017 16 Jun, 2018
Familial Mediterranean Fever is 3X more likely if poor Vitamin D Receptors (males) – Sept 2017 13 Jun, 2018
UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017 15 May, 2018
Adolescent idiopathic scoliosis 2 X more likely in Asians with poor Vitamin D Receptor 08 May, 2018
Neonatal Sepsis 4.8 X more likely if poor Vitamin D receptor – June 2018 22 Apr, 2018
Thyroid and vitamin D are the only body components which have a receptor on every cell in the body 19 Apr, 2018
Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018 14 Apr, 2018
Vitamin D receptor is activated somewhat by ginger, thyme, coriander, and lemongrass – March 2018 08 Apr, 2018
Lumbar Degenerative Disc Disease 3X more likely if poor Vitamin D Receptor – March 2018 02 Apr, 2018
Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018 28 Mar, 2018
Degeneration of lumbar disc 2.5 X more likely if poor Vitamin D receptor (not detected by test) Feb 2018 26 Mar, 2018
Metabolic Syndrome risk increases about 70 percent if poor Vitamin D Receptor 20 Mar, 2018
Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018 17 Mar, 2018
Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018 14 Mar, 2018
Respiratory Tract Infections in children 7.4 X more likely if poor Vitamin D Receptor – 2008 11 Feb, 2018
Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017 04 Feb, 2018
Do you have a Vitamin D Receptor Mutation (and might need more vitamin D) – Jan 2018 24 Jan, 2018
Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017 03 Jan, 2018
A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy 31 Dec, 2017
Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017 29 Dec, 2017
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 14 Dec, 2017
Preterm birth far more likely if previous miscarriage and poor Vitamin D receptor – Aug 2017 20 Nov, 2017
Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017 20 Nov, 2017
Olmesartan (blood pressure drug Benecar) improves Vitamin D Receptor by an unknown amount 20 Nov, 2017
Large amounts of curcumin might activate the Vitamin D receptor – Dec 2010 14 Nov, 2017
Preterm birth is related to Vitamin D Receptor problems – many studies agree 13 Nov, 2017
Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc 13 Nov, 2017
Preterm birth and Vitamin D Receptor – Dec 2016 13 Nov, 2017
Obesity in 700 young males associated with a poor Vitamin D Receptor – Jan 2018 13 Nov, 2017
Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018 13 Nov, 2017
Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017 12 Nov, 2017
Weaker hand grip if poor Vitamin D Receptor (15 percent) – Nov 2016 12 Nov, 2017
Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017 12 Nov, 2017
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
TB risk in Blacks increased 20 percent having poor Vitamin D Receptors – Sept 2017 26 Oct, 2017
Vitamin D receptors not detected in some tissues – July 2012 22 Oct, 2017
Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017 19 Oct, 2017
UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017 09 Oct, 2017
Cancer and the Vitamin D Receptor, a primer – Sept 2017 01 Oct, 2017
Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017 14 Sep, 2017
Speculation – Weekly vitamin D dose will be better than daily if poor Receptor 12 Sep, 2017
Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017 07 Sep, 2017
Vitamin D Receptor Activator might help treat or prevent various diseases 27 Aug, 2017
Vitamin D Receptor activators (such as paricalcitol) treat dialysis patients similarly – Aug 2017 27 Aug, 2017
Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017 26 Aug, 2017
Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004 25 Aug, 2017
Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017 19 Aug, 2017
Cancer risks and Vitamin D Receptors – association is unclear – 2017 19 Aug, 2017
Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016 09 Aug, 2017
Immune system is aided by red grapes, blueberries, both of which increase Vitamin D receptor – 2013 04 Aug, 2017
Raised skin scars (keloid) have fewer Vitamin D Receptors – Aug 2017 03 Aug, 2017
Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017 02 Aug, 2017
Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016 27 Jul, 2017
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 27 Jul, 2017
Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 25 Jul, 2017
Aging leads to a decrease in vitamin D receptor number in several organs (behind paywall) – Sept 2017 25 Jul, 2017
Centenarians have good Vitamin D Receptors (longevity is also increased by higher Vit D levels) – Aug 2016 24 Jul, 2017
Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017 24 Jul, 2017
Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017 14 Jul, 2017
Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017 13 Jul, 2017
Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016 05 Jul, 2017
Prostate surgery outcomes vary with Vitamin D Receptors– May 2017 16 Jun, 2017
Prostate cancer outcomes vary with Vitamin D Receptors– May 2017 16 Jun, 2017
Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015 15 Jun, 2017
Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017 15 Jun, 2017
The vitamin D receptor and T cell function – June 2013 11 May, 2017
Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017 23 Apr, 2017
Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017 20 Apr, 2017
Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013 20 Apr, 2017
Created by admin. Last Modification: Monday October 3, 2022 16:22:58 GMT-0000 by admin. (Version 7)
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022        
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