Are Adequate Vitamin D Levels Helpful in Fighting COVID-19? A Look at the Evidence
Horm Metab Res. 2020 Sep 17. doi: 10.1055/a-1243-5462
Caroline Wei Shan Hoong # 1, Koh Huilin # 1, Sanda Cho 2,
Veeraraghavan Meyyur Aravamudan # 1,Jaime Hui Xian Lin # 1
Fewer deaths if higher D
Fewer cases if higher D
Data points
Mortality and case data from Worldometer as of May 23
VitaminDWiki
Many more trials are in the pipeline
Click on chart for details
Recent updates on VitaminDWiki
Includes the RCT from Spain as of Sept 20
Top Vitamin D and COVID-19 recent updates
- COVID-19 2.7 X more likely to be severe if less than 30 ng of vitamin D (China) – Jan 2021
- 2.7 fewer COVID-19 hospital deaths in those having more than 30 ng of vitamin D – Mayo Jan 9, 2021
- Vitamin D Help Us Fight Infections - interview of Dr. Thakkar (transcript) Jan 20, 2021
- COVID-19 onset strongly associated with latitude in Europe (Vitamin D)– Jan 21, 2021
- France: 73 experts and 6 academies recommend vitamin D to prevent COVID-19 Jan 19, 2021
- Elderly COVID-19 patients getting 400,000 IU of vitamin D had better survival (Italy, April)– Jan 14, 2021
- Vitamin D-COVID interview by Dr. Campbell of Davies (member of UK Parliament) - Jan 17, 2021
- Iranians with COVID-19 were 2.3 X more likely to die if low vitamin D – Jan 2021
- Many COVID-19 risks are associated with low vitamin D (7 studies) – Systematic Review Jan 2021
- 40 ng of Vitamin D to fight COVID 15K to 50K weekly or 100K monthly - Spanish Jan 2021
- Poor COVID-19 prognosis was 6 X more likely if low vitamin D – Jan 21, 2021
- Unraveling the roles of vitamin D status and melanin during COVID-19 (Review) Jan 11
- 30 x fewer COVID-19 deaths in those getting 400,000 IU of Vitamin D - Jan 2021
- 2.8 X fewer COVID-19 nursing home deaths if add 10,000 IU Vitamin D daily for a week (small observation)- Jan 2021
- 3.7 X less likely to die of COVID-19 if supplemented with Vitamin D - meta-analysis Jan 5, 2021
- COVID-19 test positive 4.5 X more likely if had low vitamin D test within 4 years – Jan 6, 2021
- Don’t Let COVID-19 Patients Die With Vitamin D Deficiency - Jan 5, 2021
- Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis Jan 6, 2021
- Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis - Jan 5, 2021
- COVID 19 Video - Drs. Seheult and Campbell : Lessons Learned and a Look Ahead - Jan 4
- Many drugs increase ACE2 and COVID-19 (176 page review) - Dec 2020
- Italian nursing home COVID-19 – 4X less likely to die if taking Vitamin D– Dec 22, 2020
- Take 50,000 IU of Vitamin D weekly before and after COVID-19 vaccination by VItaminDWiki
- COVID-19 lung infection upsets Vitamin D genes (so more or different form of Vit D is required) - Dec 22, 2020
- COVID-19 Disease and Vitamin D: A Mini-Review – Dec 15, 2020
- French Consensus – 200,000 IU of Vitamin D if get COVID-19 – Dec 22, 2020
- Rational approach to COVID-19: 50k-100k of Vitamin D weekly – Dec 2020
- Shift workers 2X more likely to get COVID-19 (low Vitamin D) - Dec 2020
- COVID-19 plus pneumonia in ICU with low vitamin D equaled Death - Dec 2020
- Excellent on-going analysis of Vitamin D and COVID-19 publications
- 7X less likely to die of COVID-19 if taking Vitamin D loading dose – Dec 11, 2020
- COVID-19 patients with low vitamin D had far fewer natural killer cells – Dec 2020
- COVID-19 Vitamin D: Overview of Evidence by Dr. Seheult (Video and transcript) - Dec 10, 2020
- 75 articles indicate that Vitamin D should fight COVID-19 – Evidence Review Dec 10, 2020
- COVID-19 Vitamin D: Overview by Dr. in Sri Lanka (Video and transcript) - Dec 8, 2020
- Vitamin D recommended to fight COVID-19 by 2 groups – Dec 7, 2020
- Vitamin D helps athletes while reducing their COVID-19 risk - Dec 4, 2020
- 5X more likely to test positive for COVID-19 if low vitamin D in previous 5 years (900,000 people) - Dec 4, 2020
- 5.8 X more likely to die of COVID-19 if low vitamin D - Systematic Review Dec 3, 2020
- Evidence of Vitamin D fighting COVID-19 etc. - take 4,000 IU if less than 20 ng (UK) – Dec 1, 2020
- 3.8 X higher risk of COVID-19 death if low vitamin D – Belgium Nov 25, 2020
- Hyperglycemic 2X more likely to have severe COVID-19 - Nov 2020 Diabetes
- COVID-19 protocol proposed in India includes Vitamin D - Nov 12, 2020
- A Medical School COVID-19 protocol includes Vitamin D for all phases – Marik Nov 2020
- Vitamin D has eliminated ICU COVID-19 in hospital in Dubai since June - Sept 26, 2020
- COVID-19 and Vitamin D: Health Authorities do not understand risk-reward – Nov 2020
- c19study.com/d has excellent synopsis of Vitamin D and COVID studies
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click to see 3 weeks in Nov 2020
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- COVID-19 – Putative Roles of Vitamin D – Nov 2020
- Fight COVID-19 without drugs or vaccines, Vitamin D is the single most-studied way – Nov 2020
- Hospital COVID-19 observation: 7X more likely to live if more than 20 ng of vitamin D– Nov 19, 2020
- Higher vitamin D associated with fewer cases and deaths in India Nov 2020
- COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020
- 2X fewer COVID-19 deaths observed if infrequent vitamin D (2X more deaths if daily dose) – ClinicalTrial Oct 20, 2020
- Vitamin D and COVID-19 - observational studies found it helps, never hurts - Campbell Oct 31, 2020
- COVID-19 patients who happened to be taking Vitamin D did much better – Oct 27,2020
- 9X COVID-19 survival in nursing home if had 80,000 IU dose of vitamin D in previous month – Oct 2020
- Virtually no COVID-19 cases in countries having more than 30 ng of Vitamin D - Sept 17, 2020
- Rate of COVID-19 test positive is 40 pcnt lower if high vitamin D (192,000 people) - Holick Sept 2020
Download the PDF from sci-hub via VitaminDWiki
COVID-19 is a global pandemic with high mortality in vulnerable groups. Given the current lack of definitive treatment or vaccine that significantly reduces mortality rate, governments, researchers and healthcare providers are racing to find possible solutions to the crisis. Vitamin D and its analogues have been previously studied for their non-skeletal benefits. In particular, questions regarding their role in the modulation of immunity have re-surfaced, in view of possible epidemiological links observed between COVID-19 and vitamin D levels in selected populations. In this review, we highlight potential mechanisms and summarise the evidence for and against the potential role of vitamin D supplementation in our fight against COVID-19.
References for the table
- 81) Forrest KYZ, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 2011; 31: 48-54
- Sarafin K, Durazo-Arvizu R, Tian L et al. Standardizing 25-hydroxyvita- min D values from the Canadian Health Measures Survey. Am J Clin Nutr 2015; 102: 1044-1050
- Eloi M, Horvath DV, Szejnfeld VL et al. Vitamin D deficiency and seasonal variation over the years in Sao Paulo, Brazil. Osteoporos Int 2016; 27: 3449-3456
- Karonova T, Andreeva A, Nikitina I et al. Prevalence of Vitamin D deficiency in the North-West region of Russia: A cross-sectional study. J Steroid Biochem Mol Biol 2016; 164: 230-234
- Rabenberg M, Scheidt-Nave C, Busch MA et al. Vitamin D status among adults in Germany--results from the German Health Interview and Examination Survey for Adults (DEGS1). BMC Public Health 2015; 15: 641
- LJM Boonman-de Winter, Albersen A, Mohrmann K et al. High prevalence of vitamin D deficiency in the south-west Netherlands. Ned Tijdschr Geneeskd 2015; 159: A8167
- Larose TL, Chen Y, Camargo CA et al. Factors associated with vitamin D deficiency in a Norwegian population: the HUNT Study. J Epidemiol Community Health 2014; 68: 165-170
- Nakamura K, Kitamura K, Takachi R et al. Impact of demographic, environmental, and lifestyle factors on vitamin D sufficiency in 9084 Japanese adults. Bone 2015; 74: 10-17
- Wat WZM, Leung JYY, Tam S et al. Prevalence and impact of vitamin D insufficiency in southern Chinese adults. Ann Nutr Metab 2007; 51: 59-64
- Lu H-K, Zhang Z, Ke Y-H et al. High prevalence of vitamin D insufficiency in China: Relationship with the levels of parathyroid hormone and markers of bone turnover. PLoS One 2012; 7: e47264
- Gill TK, Hill CL, Shanahan EM et al. Vitamin D levels in an Australian population. BMC Public Health 2014; 14: 1001
- Vitamin D. Status of New Zealand Adults [Internet]. Ministry of Health NZ. [cited 2020 May 26]
- Mogire RM, Mutua A, Kimita W et al. Prevalence of vitamin D deficiency in Africa: A systematic review and meta-analysis. Lancet Glob Health 2020; 8: e134-e142
- Hosseinpanah F, Yarjanli M, Sheikholeslami F et al. Associations between vitamin D and cardiovascular outcomes; Tehran Lipid and Glucose Study. Atherosclerosis 2011; 218: 238-242
- Solak I, Cihan FG, Mercan S et al. Evaluation of 25-Hydroxyvitamin D Levels in Central Anatolia, Turkey. Biomed Res Int 2018; 4076548
- 96) Batieha A, Khader Y, Jaddou H et al. Vitamin D status in Jordan: dress style and gender discrepancies. Ann Nutr Metab 2011; 58: 10-18