Prevention of urinary tract infections with vitamin D supplementation 20,000 IU per week for five years. Results from an RCT including 511 subjects
Infectious Diseases, DOI:10.1080/23744235.2016.1201853
Rolf Jorde, Stina T. Sollid, Johan Svartberg, Ragnar M. Joakimsen, Guri Grimnes & Moira Y. S. Hutchinson
Background: In observational studies vitamin D deficiency is associated with increased risk of infections, whereas the effect of vitamin D supplementation in randomized controlled trials is non-conclusive.
Methods: Five hundred and eleven subjects with prediabetes were randomized to vitamin D3 (20,000?IU per week) versus placebo for five years. Every sixth month, a questionnaire on respiratory tract infections (RTI) (common cold, bronchitis, influenza) and urinary tract infection (UTI) was filled in.
Results: Mean baseline serum 25-hydroxyvitamin D (25(OH)D) level was 60?nmol/L. Two hundred and fifty-six subjects received vitamin D and 255 placebo. One hundred and sixteen subjects in the vitamin D and 111 in the placebo group completed the five-year study. Eighteen subjects in the vitamin D group and 34 subjects in the placebo group reported UTI during the study (p?<?0.02), whereas no significant differences were seen for RTI. The effect on UTI was most pronounced in males. The effect of vitamin D on UTI was unrelated to baseline serum 25(OH)D level.
Conclusion: Supplementation with vitamin D might prevent UTI, but confirmatory studies are needed.
Suspect similar results if take 50,000 IU of Vitamin D once every 2 weeks
High dose vitamin D may improve lower urinary tract symptoms in postmenopausal women.
J Steroid Biochem Mol Biol. 2017 Oct;173:28-32. doi: 10.1016/j.jsbmb.2017.03.013. Epub 2017 Mar 18.
Oberg J1, Verelst M2, Jorde R3, Cashman K4, Grimnes G5.
Lower urinary tract symptoms (LUTS) are common in postmenopausal women, and have been reported inversely associated with vitamin D intake and serum 25-hydroxyvitamin D (25(OH)D) levels. The aim of this study was to investigate if high dose vitamin D supplementation would affect LUTS in comparison to standard dose. In a randomized controlled study including 297 postmenopausal women with low bone mineral density, the participants were allocated to receive capsules of 20 000IU of vitamin D3 twice a week (high dose group) or similar looking placebo (standard dose group). In addition, all the participants received 1g of calcium and 800IU of vitamin D daily. A validated questionnaire regarding LUTS was filled in at baseline and after 12 months. At baseline, 76 women in the high dose group and 82 in the standard dose group reported any LUTS. Levels of serum 25(OH)D increased significantly more in the high dose group (from 64.7 to 164.1nmol/l compared to from 64.1 to 81.8nmol/l, p<0.01). No differences between the groups were seen regarding change in LUTS except for a statistically significant reduction in the reported severity of urine incontinence in the high dose group as compared to the standard dose group after one year (p<0.05). The results need confirmation in a study specifically designed for this purpose.
Copyright © 2017 Elsevier Ltd. All rights reserved.
PDF is available at https://www.deepdyve.com PMID: 28323043 DOI: 10.1016/j.jsbmb.2017.03.013
- Search VitaminDWiki for "Urinary tract infection" OR UTI 247 items as of Sept 2017
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