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Upper Respiratory Tract Infections in adults reduced by just 400 IU of vitamin D – RCT Dec 2020

Intake of 25-Hydroxyvitamin D 3 May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study

Nutrients, 2020 Dec 8;12(12):E3769. doi: 10.3390/nu12123769.
Yoshiki Shimizu 1, Yukihiko Ito 1, Nobuo Uotsu 1, Kei Yui 1


It is rare to find that as little as 400 IU of Vitamin D produces a benefit in adults

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Not clear what the numbers represent

Mental Not clear what the numbers represent

Fewer UTRI events - but not statistically significant

To evaluate the effects of 25-hydroxyvitamin D3 (25OHD) on symptoms at the onset of the upper respiratory tract infection (URTI) in subjects with insufficient or deficient serum 25-hydroxyvitamin D levels, we conducted a post hoc analysis of data from a randomized, placebo-controlled study; the subjects received 10 μg of 25OHD per day or a placebo for 16 weeks. The Wisconsin Upper Respiratory Symptom Survey-21 was used to determine URTI. The study endpoints included WURSS-21 scores, number of URTI events, and proportion of medication (antibiotics, antipyretic analgesics) usage. We found that the physical symptom scores for "Runny nose," "Sneezing," and "Head congestion" were significantly lower in the 25OHD group than in the placebo group; for all items except "Breathe easily, "the quality of life" scores were significantly improved in the 25OHD group. There was no significant difference in the number of URTI events or the proportion of medication use between the groups. Collectively, the findings of this study indicate that a sufficient 25OHD intake can reduce physical symptoms at the onset of upper respiratory tract infection, particularly nasal symptoms, and may improve the quality of life at the time of onset.

Created by admin. Last Modification: Friday January 15, 2021 17:20:23 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
14705 UTRI events.jpg admin 12 Dec, 2020 12:42 48.20 Kb 79
14704 RTI Mental table.jpg admin 12 Dec, 2020 12:42 93.04 Kb 69
14703 URTI table.jpg admin 12 Dec, 2020 12:41 86.34 Kb 68
14702 URTI 400 IU RCT.pdf PDF 2020 admin 12 Dec, 2020 12:40 254.48 Kb 60
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