Loading...
 
Toggle Health Problems and D

UK vitamin D levels vs race and obesity (all less than 30 ng) – April 2024


Ambient ultraviolet-B radiation, supplements and other factors interact to impact vitamin D status differently depending on ethnicity: A cross-sectional study

Margaret M. Brennan, Jos van Geffen, Michiel van Weele, Lina Zgaga 1, Rasha Shraim 1
Clinical Nutrition April 11, 2024 https://doi.org/10.1016/j.clnu.2024.04.006

Image
Note: A person far from the equator and outdoors for 3 hours
  WIll get little vitamin D if only morning or late afternoon
  With dark skin will get little vitamin D
  A person with concealing clothes will get little Vitamin D

Background & aims
Many determinants of vitamin D status have been well-described, yet supplementation guidelines largely follow a one-size-for-all model and deficiency remains common. We hypothesised that accounting accurately for ultraviolet-B (UVB) radiation and considering interactions could advance understanding of vitamin D status.
Methods
Asian, Black, and White participants from the UK Biobank cohort were included (N = 438,978). The Tropospheric Emission Monitoring Internet Service provided UVB data which we linked to participants' place of residence. UVB dose over 135 days prior to blood draw was weighted and added, yielding cumulative and weighted UVB (CW-D-UVB). The association between 25(OH)D and selected variables was assessed in multivariable linear regression models with and without interactions, stratified by ethnicity. Predictors were ranked using standardised β-coefficients.
Results
Median 25(OH)D differed by ethnicity (Asian: 25.4 nmol/L (10.2 ng/mL), Black: 30.6 nmol/L (12.2 ng/mL), White: 47.9 nmol/L (19.2 ng/mL), p-value < 0.001). CW-D-UVB was strongly associated with 25(OH)D in all ethnicities. It was the most important predictor in White (βAsian = 0.15, βBlack = 0.20, βWhite = 0.35), whereas supplementation was in Asian and Black participants (βAsian = 0.30, βBlack = 0.24, βWhite = 0.21). We identified statistically significant interactions between BMI:supplementation (all), CW-D-UVB:sex (Asian and White), and CW-D-UVB:age (Black and White), and in White population between CW-D-UVB and supplementation, BMI, and cholesterol.
Conclusion
Vitamin D deficiency was widespread, particularly among non-White individuals. UVB was a strong predictor of 25(OH)D and the effect was modified by other factors. Findings suggest that accurately measured ambient-UVB radiation and interactions could improve 25(OH)D prediction models, and support personalised approaches to vitamin D optimisation.
 Download the PDF from VitaminDWiki


VitaminDWiki – Overview Obesity and Vitamin D contains:

Obese need more Vitamin D
Image

  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study


VitaminDWiki – Overview Dark Skin and Vitamin D contains

FACT - - People with dark skins have more health problems and higher mortality rate than those with light skins
FACT - - People with dark skins have low levels of vitamin D
FACT - - People with light skins who have low vitamin D have health problems
OBSERVATION - - The health problems of whites with low level of vitamin D are similar to those with dark skins
CONCLUSION - - People with dark skins have more health problems due to low levels of vitamin D
African American Health Disparities are associated with low Vitamin D - Grant Feb 2021
Low Vitamin D increases health problems - independent of skin color
Image

Dark Skin studies: Pregnancy (28 studies),  Genetics (13 studies),  Vitamin D Binding Protein (8 studies),  Vitamin D Receptor (7 studies),  Diabetes (24 studies),   Cardiovascular (18 studies),  Mortality (12 studies), Intervention (16 studies) Click here to see the studies

VitaminDWiki – Blacks die more often than whites of many diseases (they have less vitamin D) – 2012

Cancer Facts & Figures for African Americans Cancer.org

  • “African Americans have the highest death rate and shortest survival of any racial and ethnic group in the US for most cancers”
  • Has a huge number of tables and charts, Note: Vitamin D is not mentioned

Leading Causes of Death as of March 2018

All Ages Death rateBlackWhiteRatio
Heart diseases 217 1711.27
Cancer 1991701.17
Cerebrovascular diseases51361.4
Diabetes 40 192.0

Rates per 100,000    Age adjusted   Non-Hispanic


VitaminDWiki – Overview Deficiency of vitamin D contains

FACT: Much of the world is now vitamin D deficient
OBSERVATION:There are many reasons that a person may be vitamin D deficient
11 of the reasons for the epidemic are new in the past 40 years, Example: Air Conditioning
OBSERVATION: The more reasons that apply to an individual, the more likely he is to be deficient (additive reasons)
FACT: Vitamin D Deficiency has been associated with many diseases

FACT: Vitamin D intake can be increased by supplements, injection, UV, and sun (very little by food) 112 items

FACT: Adding vitamin D to diets has been proven E1 E2 in clinical trials to both PREVENT some and TREAT some diseases
OBSERVATION: Adding vitamin D (intervention) does PREVENT and TREAT additional diseases - more trials are underway
OBSERVATION: There are at least 10 ways to increase the response by the blood to vitamin D intake

Details at VitaminDWiki

Image Image

from DSM

DSM 2014

Attached files

ID Name Comment Uploaded Size Downloads
21188 Vit D UK race.webp admin 08 May, 2024 26.65 Kb 33
21187 UVB Vitamin D and Race_CompressPdf.pdf admin 08 May, 2024 760.78 Kb 4