Effects of vitamin D repletion on glycemic control and inflammatory cytokines in adolescents with type 1 diabetes.
Pediatr Diabetes. 2014 Dec 18. doi: 10.1111/pedi.12238. [Epub ahead of print
Shih EM1, Mittelman S, Pitukcheewanont P, Azen CG, Monzavi R.
Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA.
This study used 20,000 IU weekly (~ 2860/day)
Levels raised from 22 ng to 34 ng
Typically takes > 40 ng of vitamin D to treat a disease
See also VitaminDWiki
- T1 diabetes OR type1 diabetes in title 21 as of Nov 2014
- T1 Diabetes associated with low vitamin D - Nov 2014
- Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT
2.5X as much Vitamin D as the study on this page
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
Little is known about the relationship between vitamin D deficiency and adolescents with type 1 diabetes. On the basis of adult studies showing that vitamin D improves insulin sensitivity and decreases inflammatory cytokines linked to microvascular complications, we hypothesized that treating vitamin D deficiency in adolescents with type 1 diabetes would improve glycemia and reduce inflammatory markers.
RESEARCH DESIGN AND METHODS:
This was a randomized, prospective, crossover study of 25 adolescents with type 1 diabetes for at least a year (aged: 13-21 yr; 62% female; 62% Hispanic) and vitamin D deficiency (25-OH vitamin D ≤30 ng/mL). Subjects received vitamin D3 (20 000 IU/week) for 6 months, either immediately or after 6 months of observation.
At baseline, 63% of subjects screened were vitamin D deficient and randomized. Interleukin-6 (IL-6) was significantly higher in the vitamin D deficient group compared with the sufficient group (medians: 0.36 vs. 0.18) (p = 0.026), whereas neither C-reactive protein (CRP) nor tumor necrosis factor-α (TNF-α) differed. Vitamin D treatment increased serum levels of 25-OH vitamin D from 22 ± 5.3 to 34.3 ± 12.1 ng/mL (p < 0.01). However, treatment did not affect glycated hemoglobin (HbA1c), insulin dosage, CRP, interleukin-6 (IL-6), or TNF-α.
Vitamin D deficiency is prevalent in the adolescent type 1 diabetes population, and could be associated with changes in inflammatory markers. However, vitamin D repletion over 6 months did not affect glycemia or markers of inflammation in our study, highlighting the need for additional research to validate these findings.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.