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Trials using 1K to 14K IU of Vitamin D to treat depression had different conclusions – meta-analysis Jan 2021

Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis

Actas Esp Psiquiatr . 2021 Jan;49(1):12-23. Epub 2021 Jan 1.
Ana Lázaro Tomé 1, M José Reig Cebriá 2, Aurora González-Teruel 3, Juan Antonio Carbonell-Asíns 4, Carlos Cañete Nicolás 5, Miguel Hernández-Viadel 5

Trials using infrequent high doses did much better
Image

VitaminDWiki

Meta-analyses of Vitamin D and Depression

Depression summary

Better than Daily has the following

Non-daily (Bolus) is sometimes better - Possible reasons include:

  1. Better compliance
    • Fewer opportunities to forget
    • Fewer times to have to take a pill - for those who dislike it
  2. High concentration resulting from infrequent dosing gets past some gene and gut limitations
    • Note: Many studies have found non-daily to be better than daily
      I am unaware of a single study which has found daily to be better than non-daily - Founder of VitaminDWiki Dec 2019

 Download the PDF from VitaminDWiki

Vitamin D is a fat-soluble vitamin that performs multiple functions in the body. In addition to regulating calcium and phosphate levels in the body and contributing to bone mineralization, it participates in various brain and neurocognitive processes. In fact, the deficiency of this vitamin has also been linked to various psychiatric disorders, including depression.


Created by admin. Last Modification: Sunday April 25, 2021 01:32:48 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
15495 Depression meta.jpg admin 25 Apr, 2021 01:28 29.75 Kb 59
15494 Depression and vitamin D meta.pdf PDF 2021 admin 25 Apr, 2021 01:15 642.90 Kb 17
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