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Trial to see if vitamin D (60,000 IU monthly) will reduce mortality – results due 2024

The D-Health Trial: A randomized trial of vitamin D for prevention of mortality and cancer

Contemporary Clinical Trials, Available online 14 April 2016, doi:10.1016/j.cct.2016.04.005
R.E. Nealea, , , B.K. Armstrongb, C. Baxtera, B. Duarte Romeroa, P. Ebelingc, D.R. Englishd, M.G. Kimline, D.S.A. McLeoda, R.L. O′Connellf, J.C. van der Polsg, A.J. Vennh, P.M. Webba, D.C. Whitemana, L. Wocknera

VitaminDWiki Summary

VitaminDWiki expects that little results will be found with 60,000 IU monthly
Elderly need at least 50,000 IU weekly, not monthly, and, one size does NOT fill all
    Random Controlled trials rarely use dose sizes which vary by weight, pre-existing conditions, etc.
See also VitaminDWikii

10 reasons why seniors need more vitamin D has the following

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
    (The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
  3. Seniors are indoors more than when when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
  5. Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  6. Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Seniors not have as much Magnesium needed to use vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

The Meta-analysis of Mortality and Vitamin D are listed here:

The Meta-analysis of Mortality and Intervention are listed here:


Promising Vitamin D Clinical Trials - 2017 contains the following

Future Clinical Trials

  • Each page includes links to similar studies/trials
  • The year is shown as 1 year after trial starts, note sometimes publication does not occur until 4 years later.
  • These clinical trials were selected as being likely to show good results by VitaminDWiki in 2017.
  • If an item is of interest. you should consider taking Vitamin D and perhaps other supplements such as Magnesium, Omega-3, and Vitamin K rather than waiting for the results of the clinical trial to be published, or waiting several decades for your doctor to incorporate the results into his practice

See also VitaminDWiki

Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Weight Loss + Growing Pain   (22 problems)


Background:
Vitamin D, specifically serum 25(OH)D has been associated with mortality, cancer and multiple other health endpoints in observational studies, but there is a paucity of clinical trial evidence sufficient to determine the safety and effectiveness of population-wide supplementation. We have therefore launched the D-Health Trial, a randomized trial of vitamin D supplementation for prevention of mortality and cancer. Here we report the methods and describe the trial cohort.

Methods:
The D-Health Trial is a randomized placebo-controlled trial, with planned intervention for 5 years and a further 5 years of passive follow-up through linkage with health and death registers. Participants aged 65–84 years were recruited from the general population of Australia. The intervention is monthly oral doses of 60,000 IU of cholecalciferol or matching placebo. The primary outcome is all-cause mortality. Secondary outcomes are total cancer incidence and colorectal cancer incidence.

Results: We recruited 21,315 participants to the trial between February 2014 and May 2015. The participants in the two arms of the trial were well-balanced at baseline. Comparison with Australian population statistics shows that the trial participants were less likely to report being in fair or poor health, to be current smokers or to have diabetes than the Australian population. However, the proportion overweight or with health conditions such as arthritis and angina was similar.

Conclusions:
Observational data cannot be considered sufficient to support interventions delivered at a population level. Large-scale randomized trials such as the D-Health Trial are needed to inform public health policy and practice.

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