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Treatment of malnourished children greatly augmented by Vitamin D – RCT May 2018

High-dose vitamin D3 in the treatment of severe acute malnutrition: a multicenter double-blind randomized controlled trial

The American J. of Clinical Nutrition, Vol 107, Issue 5, 1 May 2018, Pages 725–733, https://doi.org/10.1093/ajcn/nqy027
Javeria Saleem Rubeena Zakar Muhammad Z Zakar Mulugeta Belay Marion Rowe Peter M Timms Robert Scragg Adrian R Martineau

VitaminDWiki

Malnurished Paskistani children aged 6-58 months
Just two doses of 200,000 IU of vitamin D: At two and four weeks after starting malnutrition treatment
3.4 X less likely to have delayed gross motor development
2 X less likely to have delayed global development
1.7 X less likely to have delayed language development

  • Author indicated in an interview that he decided on the trial becasue vitamin D was being added locally and he wanted to see if it actually was helping

See also VitaminDWiki


Comments by Henry Lahore, founder of VitaminDWiki

Nice.
Had not seen this kind of thing before
Wonder if the benefit might be due to:

  1. Vitamin D reducing inflammation in the body (which would also be true for increased Omega-3)
  2. Vitamin D improved efficiency of the gut and/or liver
  3. https://www.vitamindcouncil.org/inflammatory-bowel-disease-the-one-thing-vitamin-d-and-bacteria-may-have-in-common/Vitamin D improved the gut bacteria Vitamin D CouncilMay, 2018

 Download the PDF from Sci-Hub via VitaminDWiki

Vitamin D augmented malnutrition treatment

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Background
Vitamin D deficiency is common in children with severe acute malnutrition, in whom it is associated with severe wasting. Ready-to-use therapeutic food (the standard treatment) contains modest amounts of vitamin D that do not reliably correct deficiency.

Objective
The aim of this study was to determine whether high-dose oral vitamin D3 enhances weight gain and development in children with uncomplicated severe acute malnutrition.

Design
We conducted a randomized placebo-controlled trial of high-dose vitamin D3 supplementation in children aged 6–58 mo with uncomplicated severe acute malnutrition in Pakistan. Participants were randomly assigned to receive 2 oral doses of 200,000 IU vitamin D3 or placebo at 2 and 4 wk after starting ready-to-use therapeutic food. The primary outcome was the proportion of participants gaining >15% of baseline weight at 8 wk after starting ready-to-use therapeutic food (the end of the study). Secondary outcomes were mean weight-for-height or -length z score and the proportion of participants with delayed development at the end of the study (assessed with the Denver Development Screening Tool II), adjusted for baseline values.

Results
Of the 194 randomly assigned children who started the study, 185 completed the follow-up and were included in the analysis (93 assigned to intervention, 92 to control). High-dose vitamin D3 did not influence the proportion of children gaining >15% of baseline weight at the end of the study (RR: 1.04; 95% CI: 0.94,1.15, P = 0.47), but it did increase the weight-for-height or -length z score (adjusted mean difference: 1.07; 95% CI: 0.49,1.65, P < 0.001) and reduce the proportion of participants with

  • delayed global development [adjusted RR (aRR): 0.49; 95% CI: 0.31, 0.77, P = 0.002],
  • delayed gross motor development (aRR: 0.29; 95% CI: 0.13, 0.64, P = 0.002),
  • delayed fine motor development (aRR: 0.59; 95% CI: 0.38, 0.91, P = 0.018), and
  • delayed language development (aRR: 0.57; 95% CI: 0.34, 0.96, P = 0.036).

Conclusions
High-dose vitamin D3 improved the mean weight-for-height or -length z score and developmental indexes in children receiving standard therapy for uncomplicated severe acute malnutrition in Pakistan. This trial was registered at clinicaltrials.gov as NCT03170479.

Created by admin. Last Modification: Friday May 4, 2018 12:05:50 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
9799 Weight for height - malnutrition.jpg admin 04 May, 2018 00:08 32.40 Kb 74
9798 Malnutrition + Vitamin D.pdf PDF 2018 admin 04 May, 2018 00:07 653.27 Kb 54
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