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Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT Feb 2012

Highlights of the paper from Vitamin D Council

which is behind a paywall

  • 80 infants: 40 got 1000 IU of vitamin D daily, 40 got no vitamin D
  • % of blood normally emptied from heart 55-60
  • % of blood emptied by infants with poor function 30% at beginning of study
  • % of blood emptied by vitamin D infants at the end of the vitamin D arm of the RCT 52% (virtually normal)
    Also: inflammation stopped in the infants getting vitamin D
  • % of blood emptied by other infants 43%


Vitamin D Supplementation in Infants With Chronic Congestive Heart Failure.

Pediatr Cardiol. 2012 Feb 18.
Shedeed SA.
Pediatrics Department, Zagazig University, Zagazig, Sharkia Governorate, Egypt, soadshedeed at gmail.com.

Increased circulating proinflammatory cytokines may contribute to the pathogenesis of congestive heart failure (CHF). In vitro studies have suggested that vitamin D suppresses proinflammatory cytokines and increases anti-inflammatory cytokines. The aim of this work was to evaluate the effect of vitamin D supplementation on renin-angiotensin system cytokines as well as different clinical, biochemical, and echocardiographic variables in infants with chronic CHF.

This was a double-blind, placebo-controlled intervention study and included 80 infants with CHF.

The intervention consisted of either giving Vitamin D(3) oral drops (group I) or placebo oral drops (group II).
In both study groups, baseline 25-hydroxyvitamin D [25(OH)D] concentrations were below the lower end of the reference range.

After 12 weeks of intervention, vitamin D supplementation for group I infants caused significant improvement of HF score, left-ventricular (LV) end-diastolic diameter, LV end-systolic diameter, LV ejection fraction%, and myocardial performance index together with markedly increased serum 25(OH)D and interleukin (IL)-10 and decreased PTH, IL-6, and TNF-? compared with the placebo group; these differences were statistically significant (p < 0.001).

Vitamin D supplementation has great benefits as an anti-inflammatory agent in infants with CHF.
It helps acceleration of the clinical improvement and cytokine profile balance.

PMID: 22349668

Would have been better if did not have CHF in the first place if had plenty of vitamin D before, during, and after pregnancy

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
1122 Infant CHF.gif admin 29 Feb, 2012 14.97 Kb 3859