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The role of Vitamin D in malaria – Jan 2015

J Infect Dev Ctries. 2015 Jan 15;9(1):8-19. doi: 10.3855/jidc.3687.
Khanh Vinh Quốc Luong, Lan Thi Hoàng Nguyen
Vietnamese American Medical Research Foundation, Westminster, California, United States. lng2687765 at aol.com.

An abnormal calcium-parathyroid hormone (PTH)-vitamin D axis has been reported in patients with malaria infection. A role for vitamin D in malaria has been suggested by many studies. Genetic studies have identified numerous factors that link vitamin D to malaria, including human leukocyte antigen genes, toll-like receptors, heme oxygenase-1, angiopoietin-2, cytotoxic T lymphocyte antigen-4, nucleotide-binding oligomerization domain-like receptors, and Bcl-2. Vitamin D has also been implicated in malaria via its effects on the Bacillus Calmette-Guerin (BCG) vaccine, matrix metalloproteinases, mitogen-activated protein kinase pathways, prostaglandins, reactive oxidative species, and nitric oxide synthase.

Vitamin D may be important in malaria; therefore, additional research on its role in malaria is needed.

Conclusions (Clipped from PDF)

In this paper, the relationship between vitamin D and malaria was reviewed. Genetic studies provide opportunities to determine which proteins link vitamin D to malaria pathology. Vitamin D is able to act through numerous non-genomic mechanisms, including protein expression, oxidative stress, inflammation, and cellular metabolism. Therefore, further research on the role of vitamin D in malaria is needed, and a cautious approach is advisable before recommending the widespread use of vitamin D for malaria.

 Download the PDF from VitaminDWiki.


See also VitaminDWiki


6 papers referred to this study as of Sept 2018

Effects of Vitamins in Augmentation of Malaria Treatment: A review - 2016
A, B, C, D, E
 Download the PDF from VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
10585 6-Effects-of-Vitamins-in-Augmentation-of-Malaria-Treatment-A-review.pdf admin 23 Sep, 2018 11:33 491.78 Kb 58
4921 The role of Vitamin D in malaria.pdf PDF 2015 admin 18 Jan, 2015 14:50 516.43 Kb 317
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