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The earlier the better- preconception vitamin D - June 2018.

The earlier the better: preconception vitamin D and protection against pregnancy loss.

Lancet Diabetes Endocrinol. 2018 Jun 5. pii: S2213-8587(18)30178-5. doi: 10.1016/S2213-8587(18)30178-5. Epub ahead of print
Hewison M Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham and Birmingham Health Partners, Birmingham, B15 2TT, UK. Electronic address: m.hewison at bham.ac.uk.

PDF is available free at Sci-Hub
PMID: 29884467 DOI: 10.1016/S2213-8587(18)30178-5

This is an editorial comments on
Mumford SL, Garbose RA, Kim K, et al.
Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol 2018; online May 30. http://dx.doi.org/10.1016/S2213-8587(18)30153-0.


  • Preconception supplementation appears to reduce problems with
    Becoming pregnant
    Miscarriage
  • First trimester supplementation reduces problems with
    Infant teeth
    Autism
    Asthma

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesProof
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT*
3. Gestational Diabetes 3 times RCT*
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT*
6. C-section - unplanned 1.6 timesObserve
7. Depression AFTER pregnancy 1.4 times RCT*
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT*
10. Childhood Wheezing 1.3 times RCT*
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT*
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT*
16. Childhood Respiratory Tract visits 2.5 times RCT*

Fertility and Sperm category contains the following summary

84 items in Fertility or Sperm in VitaminDWiki

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Conception and vitamin D snapshot as of 2012


Fertility

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