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Teens with low vitamin D were 4.2 X more likely to have metabolic syndrome – CASPIAN-V Nov 2021


Association of vitamin D status and cardio-metabolic risk factors in children and adolescents: the CASPIAN-V study

BMC Nutr. 2021 Nov 17;7(1):71. doi: 10.1186/s40795-021-00477-5.
Mostafa Qorbani 1 2, Motahar Heidari-Beni 3, Hanieh-Sadat Ejtahed 4, Gita Shafiee 5, Farid Goodarzi 2, Seyed Saeed Tamehri Zadeh 2, Majid Khademian 3, Nami Mohammadian Khonsari 6, Mohammad Esmaeil Motlagh 7, Hamid Asayesh 8, Mohammad Jabbari 2, Ramin Heshmat 2, Mehdi Ebrahimi 9, Roya Kelishadi 3

Background: Metabolic syndrome (MetS) starts from early life and is one of the important underlying factors for non-communicable diseases (NCDs) in adulthood. Controversial evidence exists on the role of vitamin D deficiency in increasing the risk of pediatric MetS.

Objective: This study aimed to assess the relationship between vitamin D level with MetS and its components in children and adolescents.

Methods: This nationwide cross-sectional study was performed as part of a surveillance program in Iran. Participants were 2596 students, aged 7 to 18 years, living in 30 provinces. In addition to filling questionnaires, a physical examination was conducted, and blood samples were collected. The serum concentration of 25-hydroxy vitamin D (25(OH)D) was measured using the direct competitive immunoassay chemiluminescence method.

Results: 2596 students with a mean age of 12.2 y (55.1% boys) were recruited. Prevalence of vitamin D deficiency and insufficiency in participants was 10.6% (n = 276), and 60.5% (n = 1570), respectively. The prevalence of MetS was higher in the vitamin D deficient group. Students with deficient vitamin D levels had higher odds of

  • MetS (OR: 4.25, 95%CI: 2.26-7.98),
  • abdominal obesity (OR: 2.24, 95%CI: 1.61-3.12),
  • low HDL-C (OR: 1.65, 95%CI: 1.18-2.30) and
  • high fasting blood sugar (OR: 2.56, 95%CI: 1.43-4.57)

in comparison to those with sufficient level of vitamin D.

Conclusion: Vitamin D deficiency was associated with increased odds of MetS and its components in the Iranian pediatric population. These findings underscore the importance of prevention and control of vitamin D deficiency in preventative programs against NCDs.

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VitaminDWiki - Metabolic Syndrome

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