Vitamin D Deficiency and Electrocardiographic Subclinical Myocardial Injury: Results from National Health and Nutrition Examination Survey‐III
Clinical Cardiology, https://doi.org/10.1002/clc.23078
Muhammad Imtiaz Ahmad MBBS Parag Anilkumar Chevli MBBS Yabing Li MD Elsayed Z. Soliman MD, MSc, MS
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Heart Attack 647 items as of May 2018
- Arrhythmia OR “atrial fibrillation” 497 items as of May 2018
- (Arrhythmia OR “atrial fibrillation”) AND Magnesium 345 items as of May 2018
- "C-Reactive Protein" 992 items as of May 2018
- TRIGLYCERIDES 863 items as of May 2018
- "Peripheral Artery Disease" 81 items as of Oct 2017
- "Sudden Cardiac Arrest" 98 items as of May 2018
- Search VitaminDWiki for CHF or "HEART FAILURE" 1220 items as of Aug 2017
- Search VitaminDWiki for Atherosclerosis 726 items as of Oct 2017
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
Association of cardiovascular disease (CVD) with non‐traditional risk factors such as vitamin D deficiency has been examined previously. An investigation of the association of vitamin D with subclinical myocardial injury (SC‐MI) based on an electrocardiographic score is a simple, cost‐effective and innovative way to explore this relationship.
This analysis included 6079 participants (58.3±13.1 years; 54.1% women) without CVD from NHANES III. A multivariable logistic regression model was used to examine the association between vitamin D categories (<20 ng/ml, 20‐29 ng/ml and >30 ng/ml(reference) and cardiac injury score (CIIS).
There was an incremental increase in the prevalence of SC‐MI across vitamin D categories with the highest prevalence in <20 ng/ml, followed by 20‐29 ng/ml and then >30 ng/ml (trend p‐value <.0001). There was a statistically significant association between vitamin D deficiency (<20 ng/ml) and SC‐MI (OR(95%CI): 1.27(1.04‐1.55), p = 0.04). This association was stronger in men than women (OR(95%CI): 1.74(1.32‐2.30) vs. 0.94(0.70‐1.25) respectively; interaction p‐value 0.002).
Vitamin D deficiency is associated with SC‐MI, especially in men. These findings may further highlight the role of non‐traditional risk factors in the development of CVD. The value of vitamin D supplementation in the prevention of myocardial ischemia and injury may warrant investigation.