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Are low levels of 25(OH) vitamin D and testosterone clinically relevant in men with paraplegia? - April 2016 $54
J Spinal Cord Med. 2016 Apr 13:1-2. [Epub ahead of print]
1a Divisions of Geriatric Medicine and Endocrinology , Saint Louis University School of Medicine , St. Louis , Missouri.
Elderly men; Paraplegia; Testosterone; Vitamin D
PMID: 27077579 Publisher wants $54 for the PDF
Serum 25(OH)D, PTH and correlates of suboptimal 25(OH)D levels in persons with chronic spinal cord injury - June 2012
Spinal Cord. 2012 Jun 19. doi: 10.1038/sc.2012.67.
Hummel K, Craven BC, Giangregorio L.
Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
Study design:Cross-sectional cohort study.
Objectives: To describe:
- (1) the prevalence of suboptimal 25-hydroxyvitamin D status (serum 25(OH)D <75?nmol?l(-1)) and to identify correlates of vitamin D deficiency;
- (2) the prevalence of secondary hyperparathyroidism (serum intact parathyroid hormone (PTH)?7.0?pmol?l(-1)); and
- (3) the relationships between serum PTH and 25(OH)D in adult men and women with chronic spinal cord injury (SCI).
Setting: Outpatient services, including an osteoporosis clinic at a tertiary spinal cord rehabilitation hospital in Ontario.
Methods:Serum levels of 25(OH)D and intact PTH were acquired at enrollment. Clinical correlates of suboptimal vitamin D status were collected via interview and chart abstraction, and identified by univariate logistic regression analysis. Pearson correlations were run to assess the relationships between serum PTH and 25(OH)D. Significance was P<0.05.
Results:Thirty-nine percent of the cohort, comprised of 62 adult men and women with chronic SCI, had suboptimal serum 25(OH)D levels.
Factors associated with suboptimal vitamin D levels included
- having vitamin D assessed in the winter months (odds ratio (OR)=7.38, P=0.001),
- lack of a calcium supplement (OR=7.19, P=0.003),
- lack of a vitamin D supplement (OR=7.41, P=0.019),
- younger age (OR=0.932, P=0.010),
- paraplegia (OR=4.22, P=0.016), and
- lack of bisphosphonate (OR=3.85, P=0.015).
Significant associations were observed between serum PTH and 25(OH)D (r=-0.304, P=0.032) and between PTH and C-telopeptide of type I collagen (CTX-I) (r=0.308, P=0.025).
Conclusions: Disruption of the vitamin D-PTH axis may contribute to the bone loss seen in the chronic SCI population.
The threshold for optimal serum 25(OH)D levels in the chronic SCI population may be higher than in the non-SCI population.
Serum 25(OH)D level are likely important risk factors contributing to declining bone mass and increased fracture risk post-SCI.
Spinal Cord advance online publication, 19 June 2012; doi:10.1038/sc.2012.67. PMID: 22710945
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