Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment
Contemp Oncol (Pozn). 2017; 21(2): 145–151, online 2017 Jun 30. doi: 10.5114/wo.2017.68623
Akshay Anand,1 Suyash Singh,1 Abhinav A. Sonkar,corresponding author1 Nuzhat Husain,2 Kul Ranjan Singh,1 Sudhir Singh,1 and Jitendra K. Kushwaha1
- Oral mucositis is associated with a variety of chemotherapy & radiation therapies of the head/neck
- Suspect that a Vitamin D mouthwash - homemade or spray would have been better than oral since vitamin D can be activated by many tissues, including the mouth
- Suspect that restoring vitamin D levels in a week would be much better than in 2 months, as the oral mucositis starts about 10 days after chemo/radiation therapy
- Overview Loading of vitamin D
- Oral cancer risk and vitamin D status, intake, and supplementation - review May 2013
- Chemotherapy might be augmented with Vitamin D – Jan 2017
- Cancer Chemotherapy and vitamin D – Review March 2013
- Chemotherapy might be amplified by vitamin D
Standard level of chemo/radiation therapy intensity can be deadly if you have a high level of vitamin D
18 items in Quality of Life category
“Oral mucositis is a common complication of cancer chemotherapy. It begins 5-10 days after the initiation of chemotherapy and lasts 7-14 days. Chemotherapy-induced oral mucositis causes the mucosal lining of the mouth to atrophy and break down, forming ulcers”
- Mucositis Wikipedia
“Oral and gastrointestinal (GI) mucositis affects almost all patients undergoing high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT), 80% of patients with malignancies of the head and neck receiving radiotherapy, and a wide range of patients receiving chemotherapy.”
“For most cancer treatment, about 5–15% of patients get mucositis”
“Seventy-five to eighty percent of bone marrow transplantation recipients experience mucositis,”
“In grade 3 oral mucositis, the patient is unable to eat solid food, and in grade 4, the patient is unable to consume liquids as well”
Radiotherapy to the head and neck Grade 3 oral mucositis - often exceeding 50% of patients
Download the PDF from VitaminDWiki
Note SPSS = swallowing performance status scale
Aim of the study
Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research.
Material and methods
Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). 45 patients with advanced oral cancer subjected to chemoradiation were evaluated for the effect of vitamin D supplementation on most observable QOL parameters such as oral mucositis, swallowing performance and overall QOL.
Vitamin D receptor expression was increased in oral neoplastic lesions. Vitamin D scores were significantly lower in cases compared to healthy controls (p = 0.002). Vitamin D supplementation significantly reduced the therapy-related toxicities in advanced cancer, thus reducing morbidity and improving QOL.
Vitamin D receptor expression is increased in premalignant lesions and oral cancer. Vitamin D insufficiency and deficiency are prevalent in patients with oral neoplastic lesions. Vitamin D supplementation has a role in reducing treatment-related toxicities, especially in advanced cancer.
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