Relationship of maternal obesity and vitamin D concentrations with fetal growth in early pregnancy
European Journal of Nutrition (2021) https://doi.org/10.1007/s00394-021-02695-w
Qianqian Zhang, Chen Zhang, Yi Wang, Jiuru Zhao, Haiyuan Li, Qianwen Shen, Xiaoli Wang, Meng Ni, Fengxiu Ouyang, Angela Vinturache, Hao Chen & Zhiwei Liu
CRL = crown-rump length
Items in both categories Obesity and Pregnancy
- Dark-skinned people have low vitamin D (Obese pregnant women in UK in this case) – Sept 2024
- Weight loss drugs increase unplanned pregnancies (perhaps due to Vitamin D) - May 2024
- Increased obesity risk in child if low vitamin D while pregnant - Feb 2023
- Low vitamin D during pregnancy increases risk of future health problems (obesity etc.) – May 2022
- Slow fetal growth if mother was obese and had low vitamin D (40 ng is good) – Oct 2021
- Fetus conceived by slender mom grown by obese mom is more likely will become obese - Sept 2020
- Autism 2.1 times more likely if obese and PCOS (relationships to vitamin D not mentioned) Oct 2016
- Prenatal soft drink resulted in 2 times more overweight babies at age 12 months (vitamin D not mentioned) – May 2016
- Infant risk of obesity increased by 50 percent if low vitamin D during pregnancy – Sept 2015
- Overweight children associated with low vitamin D during pregnancy – 2015, 2018
- High risk of extremely premature birth if high BMI (low vitamin D) – June 2013
- 1.8X increased risk of Obesity if antibiotics were used during pregnancy – Nov 2014
- Morbid obesity increases chance of extreme preemie by 3X (low vitamin D not mentioned) – June 2013
- Obese mothers with adequate vitamin D gave birth to low D and fat infants – Jan 2013
- Low vitamin D in womb linked to more weight at age 6 – May 2012
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
- Half of newborn deaths are due to excessive weight of their mothers – Oct 2010
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:Dark Skin
29 ; Depression 21 ; Diabetes 44 ; Obesity 17 ; Hypertension 44 ; Breathing 35 ; Omega-3 44 ; Vitamin D Receptor 24 Click here for details - All items in category Infant/Child
854 items - Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
- 38+ papers with Breastfed etc, in the title
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- 53+ preeclampsia studies
- 94+ studies with PRETERM in the title
- Fertility problem (PCOS) reduced by vitamin D, etc: many studies 15+
- 94+ Gestational Diabetes
- Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
- Post-partum depression and low Vitamin D - many studies 15+ studies
- Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 5+ studies
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Aug 2022
- Fertility and Sperm category listing has
142 items along with related searches - (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for detailsProblemVit. D
ReducesEvidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
Download the PDF from VitaminDWiki
To evaluate the effects of the association between first trimester vitamin D (VitD) concentrations and increased prepregnancy body mass index (BMI) on early fetal growth restriction (FGR).
Methods
This retrospective cohort study included 15,651 women with singleton pregnancy who delivered at the International Peace Maternity and Child Health Hospital between January 2015 and November 2016. Women were classified in two groups based on their serum 25(OH)D vitamin levels status: VitD sufficient (SUFF) group and VitD insufficient or deficient (INSUFF/DEF). The cut-off point for vit D concentration was 50.00 nmol/L. Comparisons were made between women with normal prepregnancy body weight (BMI 18.5–23.9 kg/m2) and overweight and obese (OWO) women (BMI > 24.0 kg/m2). Early FGR was defined as first-trimester gestational age-adjusted crown-rump length (CRL) in the lowest 20th centile of the population. Multivariate logistic regression was used to evaluate the association between maternal serum 25(OH)D levels and prepregnancy BMI with first trimester CRL and early FGR.Results
In VitD INSUFF/DEF group, the first trimester CRL was decreased (P = 0.005), and the risk of early FGR was increased by 13% (95% CI 1.04–1.24, P = 0.004) compared to the VitD SUFF group. In OWO group, the first trimester CRL was also significantly decreased (P < 0.0001), and the risk of early FGR was significantly increased by 58% (95% CI 1.40–1.78, P < 0.001) compared with normal weight group. Furthermore, there was a significant combined effect of maternal VitD concentrations and OWO on CRL (P for interaction = 0.02) and the risk of early FGR (P for interaction = 0.07).Conclusion
Sufficient first trimester serum 25(OH)D concentration was a protective factor for early fetal growth, especially among OWO mothers. Chinese Clinical Trial Registry (Registration number: ChiCTR1900027447 with date of registration on November 13, 2019-retrospectively registered).Slow fetal growth if mother was obese and had low vitamin D (40 ng is good) – Oct 2021Printer Friendly Follow this page for updates3197 visitors, last modified 17 Oct, 2021, This page is in the following categories (# of items in each category) - All items in category Infant/Child