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Risk of hot flashes decreased 6 percent for each 1 ng more Vitamin D – July 2020

The Relationship between Vitamin D and Vasomotor Symptoms During the Postmenopausal Period

Clin Lab. 2020 Jul 1;66(7). doi: 10.7754/Clin.Lab.2019.191116
Tufan Arslanca, Hilal Korkmaz, S Banu Arslanca, Bilge Pehlivanoglu, Özgül Celikel

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Background: During the postmenopausal period, hot flashes are frequent symptoms and might impact quality of life. Vitamin D deficiency is commonly seen in this period. This study aims to assess the association between vitamin D deficiency and hot flashes.

Methods: Two hundred ten postmenopausal women were recruited. The participants were divided into two groups: Group 1 consisted of postmenopausal women with hot flashes (n = 104), and Group 2 included the participants without hot flashes (n = 106).

Results: The comparison of the two groups concerning vitamin D level showed that 52 patients Group 1 had vitamin 25(OH)D levels below 20 ng/mL, whereas only 25 patients in Group 2 (p < 0.001). After adjusting for age and menopause duration, there was also a significant difference between groups (21.65 vs. 34.17, respectively, p < 0.001).

In multiple regression analysis, one unit decrease of vitamin 25(OH)D (1 - 0.941 = 0.059) increased the risk of hot flashes by 5.9%.

Conclusions: The decreases of vitamin D levels were significantly associated with hot flashes in postmenopausal women independent of age and menopause duration.

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