Meta-analysis on vitamin D receptor and cancer risk: focus on the role of TaqI, ApaI, and Cdx2 polymorphisms.
Eur J Cancer Prev. 2016 Jan;25(1):85-96. doi: 10.1097/CEJ.0000000000000132.
Serrano D1, Gnagnarella P, Raimondi S, Gandini S.
1Divisions of aCancer Prevention and Genetics bEpidemiology and Biostatistics; European Institute of Oncology, Milan Italy.
- Overview Cancer-Colon and vitamin D
- Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015
- Overview Cancer and vitamin D
The items in both Colon Cancer and Vitamin D Receptor categories are listed here:
- Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017
- Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017
- Risk of Cancer increased due to Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
Pages listed in BOTH the categories Colon Cancer and Genetics
- Many Ashkenazi Jew diseases associated with low vitamin D or poor Vit D genes
- Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
- Colorectal cancer – need more vitamin D if you have certain genes – Aug 2013
- Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014
- Gene variations were not associated with risk of colorectal cancer in Czech – June 2010
Vitamin D plays a significant role in our health, including cancer incidence and mortality. Vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) may affect its activity, influencing the risk of cancer. Several studies have investigated VDR SNPs, but the association with the risk of cancer is controversial. Here, we present a meta-analysis to assess the association of TaqI, ApaI, and Cdx2 SNPs with the risk of cancer. A systematic literature search was performed following a predefined protocol and using validated search strategies. This meta-analysis shows the summary odd ratio (SOR) overall, by cancer sites and by ethnicity.
Up to January 2014, we identified 73 independent studies with 35,525 cases and 38,675 controls.
The meta-analysis of Cdx2 gg versus GG showed a significant 12% increased risk for all cancers [SOR=1.12; 95% confidence interval (CI): 1.00-1.25].
The other SNPs analyzed did not show an overall significant association with the risk of cancer: SOR=0.98 (95% CI: 0.90-1.07) and 1.06 (95% CI: 0.95-1.19) for TaqI tt versus TT and ApaI aa versus AA, respectively.
TaqI shows a significant 43% increased risk for colorectal cancer (SOR=1.43; 95% CI: 1.30-1.58 for tt vs. TT). Strong frequency variations are present among different ethnic groups. This meta-analysis showed an overall increased risk of cancer associated with Cdx2 SNP and a specific higher risk of colorectal cancer associated with the TaqI polymorphism. The VDR genotype might become more relevant when clustered in a specific haplotype, associated with other SNPs of genes involved in vitamin D metabolism, or for specific tumors and/or patient characteristics.
PMID: 25738688 PMCID: PMC4885539