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Risk of COVID not reduced by 3,200 IU of vitamin D during 6 months (no surprise) – RCT March 2022

Vitamin D Supplements for Prevention of Covid-19 or other Acute Respiratory Infections: a Phase 3 Randomized Controlled Trial (CORONAVIT)

PrePrint March 2022, doi: https://doi.org/10.1101/2022.03.22.22271707
Jolliffe, Hayley Holt, Matthew Greenig, Mohammad Talaei, Natalia Perdek, Paul Pfeffer, Sheena Maltby, Jane Symons, Nicola Barlow, Alexa Normandale, Rajvinder Garcha, Alex Richter, Sian Faustini, Christopher Orton, David Ford, Ronan Lyons, Gwyneth Davies, Frank Kee, Christopher Griffiths, John Norrie, Aziz Sheikh, Seif Shaheen, Clare Relton, Adrian Martineau

BACKGROUND: Vitamin D metabolites support innate immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory pathogens. Randomized controlled trials of vitamin D to prevent coronavirus disease 2019 (Covid-19) have not yet reported.

METHODS: We randomly assigned 6200 U.K. adults to receive an offer of a postal finger-prick 25-hydroxyvitamin D (25[OH]D) test with provision of a 6-month supply of higher-dose vitamin D (3200 IU/d, n=1550) or lower-dose vitamin D (800 IU/d, n=1550) to those with blood 25(OH)D concentration <75 nmol/L, vs. no offer of testing or supplementation (n=3100). The primary outcome was the proportion of participants experiencing at least one swab test- or doctor-confirmed acute respiratory infection (ARI) of any cause at six months. Secondary outcomes included incidence of swab test-confirmed Covid-19.

RESULTS: Of 3100 participants offered testing, 2958 (95.4%) accepted, and 2690 (86.8%) had 25(OH)D <75 nmol/L and were sent vitamin D supplements (1356 higher-dose, 1334 lower-dose). 76 (5.0%) vs. 87 (5.7%) vs. 136 (4.6%) participants in higher-dose vs. lower-dose vs. no-offer groups experienced at least one ARI of any cause (odds ratio [OR] for higher-dose vs. no-offer 1.09, 95% CI 0.82-1.46; lower-dose vs. no-offer 1.26, 0.96-1.66). 45 (3.0%) vs. 55 (3.6%) vs. 78 (2.6%) participants in higher-dose vs. lower-dose vs. no-offer groups developed Covid-19 (OR for higher-dose vs. no-offer 1.13, 0.78-1.63; lower-dose vs. no-offer 1.39, 0.98-1.97).

CONCLUSIONS: Among adults with a high baseline prevalence of vitamin D insufficiency, implementation of a test-and-treat approach to vitamin D replacement did not reduce risk of all-cause ARI or Covid-19.

Clinical Trial NCT04579640

 Download preprint PDF from VitaminDWiki

 Download final PDF from VitaminDWiki

Major problem - did not wait for Vitamin D levels to plateau before gettng infection data

The trial appears to have started collecting data just 1 month after starting Vitamin D dosing
At that point, probably <10% had levels >40 ng. (thus very unlikely to have any benefit)

Also, even at the end of the 6 months about half of the participants still had levels <40 ng

VitaminDWiki - 36 studies have found that 5,000 IU gets only about half to >40 ng

Dose Response Dec 2015 (VDW# 7156)
Appears that would need >12,000 IU to get most >50 ng

Many studies are finding at >50 ng level of vitamin D is needed to fight COVID

COVID fought by 50 ng of Vitamin D

VitaminDWiki – Is 50 ng the level needed?

Is 50 ng of vitamin D too high, just right, or not enough contains the following

Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
ACL recovery
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors

VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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VitaminDWiki – Loading (not daily) doses quickly raise Vitamin D levels and fight Viruses

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Created by admin. Last Modification: Friday September 9, 2022 17:36:47 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
18400 CORONAVIT final.pdf admin 09 Sep, 2022 643.69 Kb 186
17291 RCT 3200.jpg admin 24 Mar, 2022 37.92 Kb 433
17290 CORONAVIT preprint.pdf admin 24 Mar, 2022 363.59 Kb 501