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Rheumatoid Arthritis 1.7 X more likely to be worse in 6 months if low vitamin D – Dec 2019

Association between Vitamin D deficiency and disease activity, disability and radiographic progression in early rheumatoid arthritis. The ESPOIR cohort.

J Rheumatol. 2019 Dec 15. pii: jrheum.190795. doi: 10.3899/jrheum.190795
Mouterde G1, Gamon E1, Rincheval N1, Lukas C1, Seror R1, Berenbaum F1, Dupuy AM1, Daien C1, Daurès JP1, Combe B1.


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RA worse if low Vitamin D

RA and Vitamin D Receptor (auto-updated)

RA Treated by Vitamin D

To evaluate the association of baseline serum level of vitamin D (vitD) with disease activity, disability and radiographic damage over the first year in early rheumatoid arthritis (RA).

Among early arthritis patients included in the ESPOIR cohort, patients with early RA were evaluated. 25OH vitamin D2D3 level was measured at baseline. Baseline associations between vitD level and DAS28-ESR, Health Assessment Questionnaire Disability Index (HAQ-DI) and van der Heijde-modified total Sharp score (mTSS) were assessed. Bivariate analysis was used to assess the association between vitD level and radiographic progression (mTSS increased by ≥1 point) or disability (HAQ-DI ≥0.5) over 12 months. Forward stepwise multiple logistic regression was used to evaluate the independent association of baseline variables and outcomes.

Among 813 patients with early arthritis, data for 645 RA patients were analyzed. VitD level was

  • <10 ng/ml (deficiency, group 1),
  • 10-30 ng/ml (low level, group 2) and
  • ≥30 ng/ml (normal, group 3)
    • for 114 (17.7%), 415 (64.6%), and 114 (17.7%) patients, respectively.

At baseline, DAS28-ESR and HAQ-DI were higher with vitD deficiency as compared with groups 2 and 3 combined (p=0.007 and p=0.001, respectively) as was mean mTSS but not significantly (p=0.076). On multivariate analysis, baseline vitD deficiency was associated with HAQ-DI at 6 months (OR=1.70) and mTSS at 12 months (OR=1.76).

VitD deficiency was associated with more active and severe disease at baseline and may predict disability and radiographic progression over 1 year in early RA patients.

Created by admin. Last Modification: Tuesday December 17, 2019 16:44:51 GMT-0000 by admin. (Version 1)
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