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Restoring Vitamin D levels to health cows did not change immune biomarkers in 30 days – Sept 2018

Effect of vitamin D treatments on plasma metabolism and immune parameters of healthy dairy cows.

Arch Anim Nutr. 2018 Jun;72(3):205-220. doi: 10.1080/1745039X.2018.1448564. Epub 2018 Mar 21.
Yue Y1,2, Hymøller L2, Jensen SK2, Lauridsen C2.
1 College of Veterinary Medicine , China Agricultural University , Beijing , China.
2 Department of Animal Science , Aarhus University , Tjele , Denmark.

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The study

  1. Deprived cows of Vitamin D for 4 months
  2. Supplemented healthy cows with Vitamin D in 5 ways for just 1 month
  3. Found no differences in immune markers at 1 month

What this study does not indicate

  • How many cows were not healthy after 4 months of no Vitamin D and did not participate
  • If unhealthy cows might have benefited from Vitamin D in 1 or more months
  • If the healthy cows in this study had any improvement at more than 1 month
    • The vitamin D levels appeared to still be increasing at 1 month


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PDF is available free at Sci-Hub  10.1080/1745039X.2018.1448564
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The objective of this study was to investigate the possible beneficial effect of vitamin D repletion on certain immune parameters of vitamin D insufficient dairy cows. Twenty dairy cows in late lactation were treated daily with vitamin D in five different ways: sunlight exposure (SUN), D2 supplementation combined with sunlight exposure (D2SUN), D2 supplementation (D2), D3 supplementation (D3), and D2 and D3 supplementation combined (D2D3). The cows had very low vitamin D levels at d 0 because of the vitamin D deprivation before the study. After 1 month of vitamin D repletion, all cows had plasma 25(OH)D levels within the normal range. Total 25(OH)D concentration was significantly higher in SUN, D2SUN and D2D3 than D2 or D3 at the end of the study. However, milk yield, as well as protein and fat content of the milk, was not influenced by vitamin D treatments. There was no difference obtained in the measured immune parameters: Leucocyte populations, somatic cell count, immunoglobulin concentrations in plasma and milk, and antigen-stimulated cytokine productions did not change in response to vitamin D repletion or difference in vitamin D sources, and no relations to plasma 25(OH)D levels were identified. Despite the fact that plasma 25(OH)D increased from a very low level to normal range, the present study did not show any effect of vitamin D repletion on the tested immune parameters of healthy dairy cows. Therefore, in this study, it was concluded that repletion to physiologically normal plasma 25-hydroxyvitamin D levels of vitamin D-depleted healthy dairy cows had no influence on immune parameters.

Created by admin. Last Modification: Thursday September 13, 2018 13:06:10 UTC by admin. (Version 5)

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10532 Cows 1.jpg admin 13 Sep, 2018 12:54 31.04 Kb 13
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