Table of contents
- VitaminDWiki
- RSV 11.8 X more likely to be life threatening if low Vitamin D – Feb 2022
- RSV is also known as Human orthopneumovirus - Wikipedia
- Serum 25-hydroxy Vitamin D Levels in Japanese Infants Younger Than 3-months Old With Respiratory Syncytial Virus Infection - July 2020
- 4.5X more Oxygen for Viral Respiratory Illness in Infants if low vitamin D - 2017
- Web
VitaminDWiki
Items in categories Infant-Child AND Breathing AND Intervention:
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016
- Respiratory Tract visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014
- 2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
Items in categories Seniors AND Breathing:
- Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021
- Vitamin D is one of the alternate COPD therapies – March 2021
- Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2020
- Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020
- Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019
- COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019
- COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis Jan 2019
- Hospital-acquired pneumonia treated by vitamin D if person was deficient – RCT Sept 2018
- COPD with obstruction: Death 1.7 X more likely with low vitamin D – Sept 2018
- Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis Sept 2017
- COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015
- Pneumonia 2.6X more likely if low vitamin D – April 2013
- Breathing by seniors harder when have low levels of vitamin D – Dec 2011
- Pneumonia Risk, intensity, and mortality all associated with low vitamin D
Items in categories Breathing and Virus:
- Croup (due to viruses) has surged with Omicron - March 2022
- Compare symptoms of Omicron, Flu and Colds
- Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022
- Italians entering hospital for breathing problems had low vitamin D (with and without COVID), Vitamin D should help – Nov 2021
- Superspreaders appears to have viscous lung fluids – Oct 2020
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- Respiratory viral infection (RSV) and low vitamin D - several studies
- Zinc, respiratory tract infections and COVID-19 – July 2020
- Vitamin D reduces viral respiratory infections – editorial April 18, 2020
- Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019
- Ultraviolet light kills cold and flu viruses, and generates Vitamin D in the skin
- Respiratory Virus risk reduced 35 percent by Vitamin D (14,000 IU weekly) – RCT Oct 2018
- Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Loss of smell may be related to low Zinc or perhaps low vitamin D
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Immune response to respiratory viruses – vitamin D connection – review May 2015
- Overview Colds and flu and Vitamin D
- Influenza reduced by 1.7 with 1200 IU D3, also reduced related asthma by 6X – RCT May 2010
RSV 11.8 X more likely to be life threatening if low Vitamin D – Feb 2022
Serum Vitamin D Levels and Life-Threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants
J Infect Dis. 2022 Feb 1;jiac033. doi: 10.1093/infdis/jiac033 $28 PDF
F Martin Ferolla 1, E Walter Yfran 1, M Gabriela Ballerini 2 3, Ana Caratozzolo 1, Analía Toledano 1, Ana C Giordano 1, Patricio L Acosta 1 2, Hamilton Cassinelli 2 3, Ignacio Bergada 2 3, M Gabriela Ropelato 2 3, María M Contrini 1, Eduardo L López 1, GUTI
Background: 25-hydroxyvitamin D (VD) effects on lung function and immune-modulation might affect RSV infection outcomes. We aimed to assess serum VD levels on admission and their association to life-RSV 11X more likely to be life threatening disease (LTD)
in previously healthy infants hospitalized with RSV.
Methods: Prospective cohort study conducted during 2017-2019. Previously healthy infants <12 months, hospitalized with a first episode of RSV infection, were enrolled. LTD was defined by the need of intensive care and ventilatory support. Serum VD levels <20 ng/ml were categorized as deficient, and between 20-29.9 ng/ml as insufficient.
Results: 125 patients were studied, 73 (58%) were male. The median age was 4 months (interquartile range [IQR]) 2-6). Twenty-two patients developed LTD. No differences were seen in viral load of cases with LTD compared to those with better outcome (P=.94).
Patients with LTD had significantly lower VD levels: median 18.4 ng/ml (IQR 15.1-26.9 ng/ml) versus 31.7 ng/ml (IQR 23.6-42.0 ng/ml), P<.001; 59% of all infants with LTD had VD levels <20 ng/ml, compared with a frequency of 12% in those with better outcome. Multivariable regression analysis confirmed VD deficiency as a risk factor for LTD (OR 11.83, 95%CI 3.89-35.9, P<.001).
Conclusions: These findings provide additional evidence for the development of preventive strategies.
Seasonal variations of respiratory viruses detected from children with respiratory tract infections in Riyadh, Saudi Arabia - 2018 Download
Respiratory Syncytial Virus Infection and Bronchiolitis Download
(RSV) accounts worldwide for more than 60% of acute respiratory infections in children and more than 80% in infants younger than 1 year and at the peak of viral season.
RSV is also a problem for SENIORS in the winter Oct 2017
- Most people contract the virus by age 2 and get it repeatedly throughout life.
- For healthy people, RSV feels like a cold.
- Its symptoms can be indistinguishable from the flu, except for the fact that RSV is less likely than the flu to cause fever.
RSV is also known as Human orthopneumovirus - Wikipedia
- " It is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood."
- "In temperate climates there is an annual epidemic during the winter months; in tropical climates, infection is most common during the rainy season."
- "In the United States, 60% of infants are infected during their first HRSV season,[2] and nearly all children will have been infected with the virus by 2–3 years of age"
- RSV is an enveloped virus, similar to Coronavirus
- Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Zoster, Epstein, Hepatitis, RSV) – March 2011
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
Serum 25-hydroxy Vitamin D Levels in Japanese Infants Younger Than 3-months Old With Respiratory Syncytial Virus Infection - July 2020
Jpn J Infect Dis. 2020 Jun 30. doi: 10.7883/yoken.JJID.2019.541
Hisashi Kawashima 1, Masahiro Kimura 1, Shinichiro Morichi 1, Shigeo Nishimata 1, Gaku Yamanaka 1, Yasuyo Kashiwagi 1
Download the PDF from VitaminDWiki
Low levels of blood vitamin D have been reported in children who have frequent respiratory tract infections. We measured serum concentrations of 25-hydroxy (OH) vitamin D in Japanese infants less than 3-months old infected with respiratory syncytial virus (RSV). Serum levels of 25-OH vitamin D of the 10 infants, excluding those with underlying diseases, were between less than 4 to 29.8 ng/mL. In 8 out of 10 subjects (80.0%), serum 25-OH vitamin D levels were less than 20 ng/mL. There was no statistically significant association between levels of 25-OH vitamin D and age, duration of admission, respiratory severity score, white blood cell count, blood gas levels, and NT-proBNP levels. Levels of serum 25-OH vitamin D in children who required hospitalization owing to RSV infection were low, indicating deficiency. These results suggested that vitamin D deficiency affects the susceptibility to RSV infection, but not the severity of the RSV respiratory infection.
4.5X more Oxygen for Viral Respiratory Illness in Infants if low vitamin D - 2017
Inverse Correlation between 25-OH Vitamin D Levels and Severity of Viral Respiratory Illness in Infants
Journal of Infectious Diseases and Epidemiology 2017, 3:030 DOI: 10.23937/2474-3658/1510030
Mary Fairchok1,3'4*, Christina Schofield1, Wei-Ju Chen2,4, Mary Pugh3,4, Hugh Bigg1, John C Arnold5 and Eugene VMillar2,4*
Background: 25-OH vitamin D levels above 30 ng/mL activate HCAP-18, which impacts the immune response to respiratory viruses. While emerging data suggests a link between low levels of 25-OH vitamin D and an increased incidence of respiratory infections, the relationship between these levels and severity of infection is unknown. We hypothesized that infants with insufficient 25-OH vitamin D levels would have more severe viral respiratory infections.
Methods: Healthy infants admitted with fever and cough or congestion were prospectively enrolled and 25-OH vitamin D levels were measured. Presumptive bacterial infections were excluded. Nasopharyngeal specimens were collected for determination of viral etiology by Polymerase chain reaction (PCR). Demographics and severity markers were recorded. Levels were categorized as sufficient (> 30 ng/ mL), or insufficient (< 30 ng/mL).
Results: We enrolled 90 subjects. 25-OH vitamin D was < 30 ng/mL in 66%. Respiratory syncytial virus (RSV) was the most common virus. On multivariable analysis, breastfeeding was the only risk factor found to be associated with insufficiency. Administration of antibiotics and intravenous fluid, and PICU admission were not significantly different in infants with insufficient levels. However, infants with insufficient vitamin D had increased durations of both
- hospitalization (1.4 days, 95% Confidence interval (CI) = 1.0-1.9 days) and
- oxygen use (2.2 days, 95% CI = 1.4-3.5 days), and used a
- higher level of oxygen supplementation (odds ratio = 4.58, 95% CI = 1.58-13.23).
Conclusions: Infants with 25-OH vitamin D insufficiency had more severe viral respiratory illnesses. Breastfeeding was associated with insufficiency. Vitamin D supplementation during pregnancy might be a strategy to reduce risk and severity of respiratory illness in infants.
Download the PDF from VitaminDWiki
Web
- Respiratory Syncytial Virus (RSV) Medicinenet June 2021
- Vitamin D is not mentioned
- What is the role of vitamin D supplementation in respiratory syncytial virus (RSV) infection prevention? Feb 2019
- "neonates born with 25-OHD concentrations lower than 50 nmol/L had a 6-fold greater risk of RSV LRTI in the first year of life than neonates with 25-OHD concentrations of 75 nmol/L or less. "
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| 16339 | Viral Respiratory Illness in Infants - 2017.pdf | admin 02 Oct, 2021 10:42 | 788.38 Kb | 80 | ||
| 13985 | RSV Adults.jpg | admin 03 Jul, 2020 14:56 | 74.28 Kb | 624 | ||
| 13984 | Respiratory Syncytial Virus Infection and Bronchiolitis.pdf | admin 03 Jul, 2020 14:48 | 1.36 Mb | 301 | ||
| 13983 | RSV percentage.jpg | admin 03 Jul, 2020 14:44 | 27.87 Kb | 626 | ||
| 13982 | Seasonal RSV SA.pdf | admin 03 Jul, 2020 14:36 | 511.78 Kb | 235 | ||
| 13981 | RSV Saudi Arabia.jpg | admin 03 Jul, 2020 14:35 | 39.60 Kb | 590 | ||
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| 13979 | Respiratory Syncytial Virus.pdf | PDF 2020 | admin 03 Jul, 2020 14:04 | 1.46 Mb | 329 |